| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:Epidermal Growth Factor Receptor
Purity:lyophilized powder, main >= 15,000units/mg protein Bradford Package:500units Remarks:E2645
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| | EPIDERMAL GROWTH FACTOR RECEPTOR Basic information |
| Product Name: | EPIDERMAL GROWTH FACTOR RECEPTOR | | Synonyms: | EGF-R;EGF RECEPTOR;EPIDERMAL GROWTH FACTOR RECEPTOR;EGFR (L861Q), active, GST tagged human;EGFR (695-end), active, GST tagged human;mENA;EGFR active mouse;ERBB | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![EPIDERMAL GROWTH FACTOR RECEPTOR Structure]() |
| | EPIDERMAL GROWTH FACTOR RECEPTOR Chemical Properties |
| storage temp. | -70°C | | form | lyophilized powder |
| Hazard Codes | B | | WGK Germany | 3 |
| | EPIDERMAL GROWTH FACTOR RECEPTOR Usage And Synthesis |
| Description | EGFR (HER1, ErbB1) is an RTK expressed on the surface of cells of mesodermal and ectodermal origin, and it mediates cell growth, proliferation, and differentiation in numerous organs [16, 17]. EGFR belongs to the ErbB family of RTKs,
which also includes HER2 (ErbB2), HER3 (ErbB3), and HER4 (ErbB4). EGFR
binds at least seven highly variable growth factor ligands [18]. Upon stimulation,
EGFR undergoes combinatorial homo- or hetero-dimerization with one of the proteins of the HER family, thereby activating an expansive signaling network [16, 19,
20]. The EGFR transmembrane protein has a large extracellular component (with 4
domains, ~620 amino acids) that primarily serves as ligand-binding sites and which
is anchored by a short helical transmembrane domain to the intracellular tyrosine
kinase domain (TKD) (Fig.?1) [18]. | | Mechanism of action | EGFR is believed to play a role in the pathogenesis of lung cancer and is overexpressed in a majority of NSCLCs [21, 22]. However, the clinical importance of
EGFR expression in the general NSCLC population is unclear. There was some
suggestion that EGFR expression may serve as a predictive biomarker [21], but this
has been superseded by mutational analysis after the identification of actionable
driver mutations in the EGFR gene. |
| | EPIDERMAL GROWTH FACTOR RECEPTOR Preparation Products And Raw materials |
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