METHOXYVERAPAMIL HYDROCHLORIDE
中文名称 | METHOXYVERAPAMIL HYDROCHLORIDE |
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中文同义词 | 盐酸戈洛帕米;化合物 T11353L;化合物GALLOPAMIL HYDROCHLORIDE |
英文名称 | METHOXYVERAPAMIL HYDROCHLORIDE |
英文同义词 | (+/-)-VERAPAMIL, METHOXY-, HYDROCHLORIDE;VERAPAMIL, (+/-)-METHOXY-, HYDROCHLORIDE;(+/-)-ALPHA-(3-[(2-[3,4-DIMETHOXYPHENYL]ETHYL)METHYLAMINO]PROPYL)-3,4,5-TRIMETHOXY-ALPHA-(1-METHYLETHYL)-BENZENEACETONITRILE HYDROCHLORIDE;GALLOPAMIL;GALLOPAMIL HCL;D600;D600, HCL;D 600 HYDROCHLORIDE |
CAS号 | 16662-46-7 |
分子式 | C28H41ClN2O5 |
分子量 | 521.09 |
EINECS号 | 2407047 |
相关类别 | |
Mol文件 | 16662-46-7.mol |
结构式 |
METHOXYVERAPAMIL HYDROCHLORIDE 性质
熔点 | 145-148° |
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储存条件 | Store at -20°C |
溶解度 | DMF:16.7mg/mL; DMSO:10mg/mL;乙醇:10mg/mL; PBS(pH 7.2):0.25 mg/mL |
形态 | 结晶固体 |
颜色 | 白色至米白色 |
Gallopamil hydrochloride (Methoxyverapamil hydrochloride) 是一种维拉帕米的甲氧基衍生物 (methoxy derivative of verapamil),也是一种苯基烷基胺钙 (phenylalkylamine calcium) 拮抗剂。Gallopamil hydrochloride 以浓度依赖性方式抑制酸分泌,IC50 为 10.9 μM。Gallopamil hydrochloride 是一种有效的抗心律不齐和血管扩张剂。
Ca 2+
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Gallopamil hydrochloride (Methoxyverapamil hydrochloride; i.v.; 0.2 mg/kg; for 5 min) markedly reduces ventricular tachycardia (VT) and totally prevents fibrillation (VF). Gallopamil significantly reduces systolic and diastolic blood pressure measured 5 min after injection without markedly influencing heart rate.
Animal Model: | Male Wistar rats weighing 290-370 g |
Dosage: | 0.2 mg/kg |
Administration: | i.v.; 5 min |
Result: | Markedly reduced VT and totally prevented VF. |
安全信息
WGK Germany | 3 |
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提供商 | 语言 |
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英文
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