| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:Monoclonal Anti-p21WAF1/Cip1 antibody produced in mouse
Purity:clone CP74, purified from hybridoma cell culture Package:.2ML Remarks:P1484-.2ML
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| | ANTI-P21 Basic information |
| Product Name: | ANTI-P21 | | Synonyms: | ANTI-WAF1 (P21), HUMAN;ANTI-WAF1 PROTEIN P21;ANTI-WAF1;ANTI-SDI1;ANTI-P21;ANTI-P21(187);ANTI-P21(C-19);ANTI-P21CIP1/WAF1 | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![ANTI-P21 Structure]() |
| | ANTI-P21 Chemical Properties |
| storage temp. | −20°C | | form | buffered aqueous solution |
| | ANTI-P21 Usage And Synthesis |
| Uses | Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)
Western Blotting (1 paper) | | General Description | Monoclonal Anti-p21WAF1/Cip1 (mouse IgG2b isotype) is derived from the CP74 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from a BALB/c mouse immunized with recombinant human p21WAF1/Cip1. p21WAF1/Cip1 is 21 kDa and designated as Cip1, WAF1, Sdi1, Pic1, CAP20. | | Biochem/physiol Actions | Regulation of cell cycle progression in eukaryotic cells depends on the expression of proteins called cyclins. These proteins form complexes with several different cyclin dependent kinases (CDKs). The catalytic activity of cyclin dependent kinases (CDK) is regulated by two general mechanisms: protein phosphorylation and association with regulatory subunits, which include the cyclins and the CDK inhibitors (CKIs). These inhibit all kinases involved in the G1/S transition. The the p16INK4a family, which includes p15INK4b, p16INK4a, p18INK4c and p19INK4d, inhibits Cdk4 and Cdk6 specifically. |
| | ANTI-P21 Preparation Products And Raw materials |
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