Log in | Join Free | china | japan | germany

2-Propynamide, 3-[5-[(4aR,8aS)-3,4,4a,5,8,8a-hexahydro-3-(1-methylethyl)-4-oxo-1-phthalazinyl]-2-methoxyphenyl]-N-(phenylmethyl)-, rel-

Request For Quotation
2-Propynamide, 3-[5-[(4aR,8aS)-3,4,4a,5,8,8a-hexahydro-3-(1-methylethyl)-4-oxo-1-phthalazinyl]-2-methoxyphenyl]-N-(phenylmethyl)-, rel- Suppliers list
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:NPD-1335
CAS:2376326-31-5
Purity:98% Package:$510.9/5mg;$820.9/10mg;Bulk package Remarks:98%
Company Name: TargetMol Chemicals Inc.  
Tel: 4008200310
Email: marketing@tsbiochem.com
Products Intro: Product Name:NPD-1335
CAS:2376326-31-5
Purity:98% Package:100 mg；5 mg；50 mg
Company Name: RD International Technology Co., Limited  
Tel: 18024082417
Email: market@ubiochem.com
Products Intro: Product Name:NPD-1335
CAS:2376326-31-5
Purity:5mg;10mg;50mg;100mg;250mg;500mg;1g Package:5mg;10mg;50mg;100mg;250mg;500mg;1g
2-Propynamide, 3-[5-[(4aR,8aS)-3,4,4a,5,8,8a-hexahydro-3-(1-methylethyl)-4-oxo-1-phthalazinyl]-2-methoxyphenyl]-N-(phenylmethyl)-, rel- Basic information
Product Name:2-Propynamide, 3-[5-[(4aR,8aS)-3,4,4a,5,8,8a-hexahydro-3-(1-methylethyl)-4-oxo-1-phthalazinyl]-2-methoxyphenyl]-N-(phenylmethyl)-, rel-
Synonyms:2-Propynamide, 3-[5-[(4aR,8aS)-3,4,4a,5,8,8a-hexahydro-3-(1-methylethyl)-4-oxo-1-phthalazinyl]-2-methoxyphenyl]-N-(phenylmethyl)-, rel-;NPD-1335
CAS:2376326-31-5
MF:C28H29N3O3
MW:455.55
EINECS:
Product Categories:
Mol File:2376326-31-5.mol
2-Propynamide, 3-[5-[(4aR,8aS)-3,4,4a,5,8,8a-hexahydro-3-(1-methylethyl)-4-oxo-1-phthalazinyl]-2-methoxyphenyl]-N-(phenylmethyl)-, rel- Structure
2-Propynamide, 3-[5-[(4aR,8aS)-3,4,4a,5,8,8a-hexahydro-3-(1-methylethyl)-4-oxo-1-phthalazinyl]-2-methoxyphenyl]-N-(phenylmethyl)-, rel- Chemical Properties
density 1.17±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
pka12.42±0.46(Predicted)
form Solid
color Off-white to light yellow
Safety Information
MSDS Information
2-Propynamide, 3-[5-[(4aR,8aS)-3,4,4a,5,8,8a-hexahydro-3-(1-methylethyl)-4-oxo-1-phthalazinyl]-2-methoxyphenyl]-N-(phenylmethyl)-, rel- Usage And Synthesis
Description

NPD1335 is a Trypanosoma brucei phosphodiesterase B1 (TbrPDEB1) inhibitor with submicromolar activities against T. brucei parasites. NPD1335 displays a greatly improved cytotoxicity profile. NPD1335 increases intracellular cAMP levels and results in the distortion of the cell cycle and cell death[1]. pKi: 6.9 (TbrPDEB1); pIC50: 6.2 (T. brucei) (NPD-1335)[1]

References

[1]. de Heuvel E, et al. Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors (Part 2). Bioorg Med Chem. 2019 Jul 5. pii: S0968-0896(19)30790-4.

2-Propynamide, 3-[5-[(4aR,8aS)-3,4,4a,5,8,8a-hexahydro-3-(1-methylethyl)-4-oxo-1-phthalazinyl]-2-methoxyphenyl]-N-(phenylmethyl)-, rel- Preparation Products And Raw materials
Tag:2-Propynamide, 3-[5-[(4aR,8aS)-3,4,4a,5,8,8a-hexahydro-3-(1-methylethyl)-4-oxo-1-phthalazinyl]-2-methoxyphenyl]-N-(phenylmethyl)-, rel-(2376326-31-5) Related Product Information