D-Phenylalanine, N-[6-[4-(phenylmethoxy)phenyl]-4-pyrimidinyl]-
中文名称 | D-Phenylalanine, N-[6-[4-(phenylmethoxy)phenyl]-4-pyrimidinyl]- |
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中文同义词 | 化合物 T26745;化合物BAY 73-1449 |
英文名称 | D-Phenylalanine, N-[6-[4-(phenylmethoxy)phenyl]-4-pyrimidinyl]- |
英文同义词 | D-Phenylalanine, N-[6-[4-(phenylmethoxy)phenyl]-4-pyrimidinyl]-;BAY 73-1449;vessel,portal,pressure,mesenteric,porto-systemic,inhibit,BAY 731449,blood,BAY 73 1449,prostacyclin,inflow,BAY 73-1449,splenic,Inhibitor,shunt,lower,Prostaglandin Receptor,outflow |
CAS号 | 693790-96-4 |
分子式 | C26H23N3O3 |
分子量 | 425.48 |
EINECS号 | |
相关类别 | |
Mol文件 | 693790-96-4.mol |
结构式 | ![]() |
D-Phenylalanine, N-[6-[4-(phenylmethoxy)phenyl]-4-pyrimidinyl]- 性质
沸点 | 700.4±60.0 °C(Predicted) |
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密度 | 1.273±0.06 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 二甲基亚砜:250 mg/mL(587.57 mM) |
酸度系数(pKa) | 3.35±0.10(Predicted) |
形态 | 固体 |
颜色 | 白色至米白色 |
IP Receptor <0.1 nM (IC 50 ) |
BAY 73-1449 (0.1-1 mg/kg; i.v.) does not significantly reduce mesenteric inflow, but significantly reduces splenic shunt vessel outflow in rats.
BAY 73-1449 (1-5 mg/kg, s.c. once daily for 7 d) has no effects on the degree of porto-systemic shunting in rats.
BAY 73-1449 (1 mg/kg, s.c. once daily for 7 d), has no effects on portal pressures in rats.
Animal Model: | Male Wistar rats (250-350 g) are ligated portal vein |
Dosage: | 0.1, 1 mg/kg |
Administration: | A single i.v. |
Result: | Significantly reduced shunt flow without affecting mesenteric flow. |
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-118941 | BAY 73-1449 | 1 mg | 1142元 | |
2024/08/19 | HY-118941 | D-Phenylalanine, N-[6-[4-(phenylmethoxy)phenyl]-4-pyrimidinyl]- BAY 73-1449 | 693790-96-4 | 5mg | 2500元 |