D-Phenylalanine, N-[6-[4-(phenylmethoxy)phenyl]-4-pyrimidinyl]-
生物活性靶点体内研究 用途与合成方法 MSDS D-Phenylalanine, N-[6-[4-(phenylmethoxy)phenyl]-4-pyrimidinyl]-价格(试剂级) 上下游产品信息
| 中文名称 | D-Phenylalanine, N-[6-[4-(phenylmethoxy)phenyl]-4-pyrimidinyl]- |
|---|---|
| 中文同义词 | 化合物 T26745;化合物BAY 73-1449 |
| 英文名称 | D-Phenylalanine, N-[6-[4-(phenylmethoxy)phenyl]-4-pyrimidinyl]- |
| 英文同义词 | D-Phenylalanine, N-[6-[4-(phenylmethoxy)phenyl]-4-pyrimidinyl]-;BAY 73-1449;vessel,portal,pressure,mesenteric,porto-systemic,inhibit,BAY 731449,blood,BAY 73 1449,prostacyclin,inflow,BAY 73-1449,splenic,Inhibitor,shunt,lower,Prostaglandin Receptor,outflow |
| CAS号 | 693790-96-4 |
| 分子式 | C26H23N3O3 |
| 分子量 | 425.48 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 693790-96-4.mol |
| 结构式 | ![D-Phenylalanine, N-[6-[4-(phenylmethoxy)phenyl]-4-pyrimidinyl]- 结构式](CAS/20210111/GIF/693790-96-4.gif) |
D-Phenylalanine, N-[6-[4-(phenylmethoxy)phenyl]-4-pyrimidinyl]- 性质
| 沸点 | 700.4±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.273±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：250 mg/mL（587.57 mM） |
| 酸度系数(pKa) | 3.35±0.10(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
BAY 73-1449 是一种选择性前列环素受体 (prostacyclin receptor, IP) 的拮抗剂，在人 HEL 细胞和大鼠 DRG 的 cAMP 分析中具有很高的效价 (IC50 值小于 0.1 nM)。BAY 73-1449 可用于降血压的研究。
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IP Receptor <0.1 nM (IC 50 ) |
BAY 73-1449 (0.1-1 mg/kg; i.v.) does not significantly reduce mesenteric inflow, but significantly reduces splenic shunt vessel outflow in rats.
BAY 73-1449 (1-5 mg/kg, s.c. once daily for 7 d) has no effects on the degree of porto-systemic shunting in rats.
BAY 73-1449 (1 mg/kg, s.c. once daily for 7 d), has no effects on portal pressures in rats.
| Animal Model: | Male Wistar rats (250-350 g) are ligated portal vein |
| Dosage: | 0.1, 1 mg/kg |
| Administration: | A single i.v. |
| Result: | Significantly reduced shunt flow without affecting mesenteric flow. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-118941 | BAY 73-1449 | 1 mg | 1142元 | |
| 2024/08/19 | HY-118941 | D-Phenylalanine, N-[6-[4-(phenylmethoxy)phenyl]-4-pyrimidinyl]- BAY 73-1449 | 693790-96-4 | 5mg | 2500元 |