| Company Name: |
SuZhou Medinoah Co.,LTD.
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| Tel: |
0512-0512-69561983 13914027025 |
| Email: |
he_qf@medinoah.com |
| Products Intro: |
Product Name:2-(2,6-dioxopiperidin-3-yl)-5-(4-(piperidin-4-yl)piperazin-1-yl)isoindoline-1,3-dione
CAS:2229716-11-2
Purity:>95% Package:5g;10g;1kg;10kg;>10kg
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| Company Name: |
Jilin Province Woda Biotechnology Co., Ltd.
|
| Tel: |
13504435624 |
| Email: |
1927928688@qq.com |
| Products Intro: |
Product Name:2-(2,6-dioxopiperidin-3-yl)-5-(4-(piperidin-4-yl)piperazin-1-yl)isoindoline-1,3-dione
CAS:2229716-11-2
Purity:99% HPLC Package:1克;5克;
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| Company Name: |
Wuhan Yuxiang Medical Technology Co., Ltd.
|
| Tel: |
13971275651 |
| Email: |
sales@whyxpharma.com |
| Products Intro: |
Product Name:2-(2,6-dioxopiperidin-3-yl)-5-(4-(piperidin-4-yl)piperazin-1-yl)isoindoline-1,3-dione
CAS:2229716-11-2
Purity:95% HPLC Package:1g;5g;10g
|
| Company Name: |
Abosyn
|
| Tel: |
0512-69561983 13914027025 |
| Email: |
he_qf@medinoah.com |
| Products Intro: |
Product Name:2-(2,6-dioxopiperidin-3-yl)-5-(4-(piperidin-4-yl)piperazin-1-yl)isoindoline-1,3-dione
CAS:2229716-11-2
Purity:>95% Package:5g;10g;1kg;10kg;>10kg
|
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| | 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-[4-(4-piperidinyl)-1-piperazinyl]- Basic information |
| | 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-[4-(4-piperidinyl)-1-piperazinyl]- Chemical Properties |
| Boiling point | 686.0±55.0 °C(Predicted) | | density | 1.367±0.06 g/cm3(Predicted) | | pka | 10.83±0.40(Predicted) |
| | 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-[4-(4-piperidinyl)-1-piperazinyl]- Usage And Synthesis |
| Biological Activity | Thalidomide-Piperazine-Piperidine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. | | References | [1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1008. |
| | 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-[4-(4-piperidinyl)-1-piperazinyl]- Preparation Products And Raw materials |
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