| Company Name: |
Shanghai Chaolan Chemical Technology Center
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| Tel: |
QQ:65489617 15618227136 |
| Email: |
info@SuperLan-chem.com |
| Products Intro: |
Product Name:VU0360172
CAS:1310012-12-4
Purity:98% Package:5MG;10MG;50MG;100MG,1G,5G,100G
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| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Email: |
sales@dcchemicals.com |
| Products Intro: |
Product Name:VU0360172
CAS:1310012-12-4
Purity:98% HPLC Package:100mg，250mg，1g
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:VU0360172
CAS:1310012-12-4
Purity:99.65% Package:1mg/RMB 497;5mg/RMB 1230;10mg/RMB 1990
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| | 3-Pyridinecarboxamide, N-cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]- Basic information |
| | 3-Pyridinecarboxamide, N-cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]- Chemical Properties |
| Boiling point | 506.8±45.0 °C(Predicted) | | density | 1.27±0.1 g/cm3(Predicted) | | storage temp. | 4°C, protect from light | | solubility | DMSO : 83.33 mg/mL (283.13 mM; Need ultrasonic) | | pka | 13.78±0.20(Predicted) | | form | Solid | | color | Light yellow to brown |
| | 3-Pyridinecarboxamide, N-cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]- Usage And Synthesis |
| Biological Activity | VU0360172 is a potent and selective mGlu5 receptor positive allosteric modulator with an EC50 value of 16 nM and a Ki of 195 nM, respectively. VU0360172 stimulates polyphosphoinositide (PI) hydrolysis in vivo, which is abrogated in mGlu5 receptors gene deleted mice[1]. | | References | [1]. Zuena AR, et al. In Vivo Non-radioactive Assessment of mGlu5 Receptor-Activated Polyphosphoinositide Hydrolysis in Response to Systemic Administration of a Positive Allosteric Modulator. Front Pharmacol. 2018 Jul 31;9:804. |
| | 3-Pyridinecarboxamide, N-cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]- Preparation Products And Raw materials |
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