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DC Chemicals
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sales@dcchemicals.com |
| Products Intro: |
Product Name:J-2156 TFA
CAS:2387505-73-7
Purity:98% HPLC Package:100mg，250mg，1g
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| Company Name: |
Beijing Jin Ming Biotechnology Co., Ltd.
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| Tel: |
010-60605840 15801484223; |
| Email: |
psaitong@jm-bio.com |
| Products Intro: |
Product Name:J-2156 TFA
CAS:2387505-73-7
Purity:98% Package:5mg;10mg;25mg;50mg;100mg
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| Company Name: |
TargetMol Chemicals Inc.
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4008200310 |
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marketing@tsbiochem.com |
| Products Intro: |
Product Name:J-2156 TFA
CAS:2387505-73-7
Package:2mg/RMB 867;10mg/RMB 2740;5mg/RMB 1490
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| Company Name: |
Nantong QuanYi Biotechnology Co., Ltd
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| Tel: |
0513-66337626 18051384581 |
| Email: |
sales@chemhifuture.com |
| Products Intro: |
Product Name:J-2156 TFA
CAS:2387505-73-7
Purity:98%+ HPLC Package:10mg，500mg，1g，2g，5g，10g，more
|
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| | J-2156 TFA Basic information |
| | J-2156 TFA Chemical Properties |
| storage temp. | Store at -20°C, protect from light, stored under nitrogen | | solubility | DMSO: 100 mg/mL (171.65 mM) | | form | Solid | | color | White to off-white | | Water Solubility | Water: 100 mg/mL (171.65 mM) |
| | J-2156 TFA Usage And Synthesis |
| Biological Activity | J-2156 TFA is a high potent, selective somatostatin receptor type 4 (SST4 receptor) agonist with IC50s of 0.05 nM and 0.07 nM for human and rat SST4 receptors, respectively. J-2156 TFA has anti-inflammatory activity and it is used for the relief of mechanical allodynia and mechanical hyperalgesia in the ipsilateral hindpaws in rats[1][2].
J-2156 TFA binds with nanomolar affinity to the human somatostatin receptor subtype 4 (hsst4: Ki=1.2 nM) and is over 400-fold subtype-selective against the other somatostatin receptors (hsst1: Ki=0.5 μM; hsst2: Ki>5 μM; hsst3: Ki=1.4 μM; hsst5: Ki=0.54 μM) in Chinese hamster ovary (CHO) cells[2].
J-2156 TFA (1-10mg/kg; i.p.; for 3 hours) of single bolus doses has anti-allodynic effect on ipsilateral and contralateral in BCIBP-rats[1]. Animal Model: Breast cancer-induced bone pain (BCIBP)-rats[1] | | storage | Store at -20°C | | References | [1]. Shenoy PA, et al. The Somatostatin Receptor-4 Agonist J-2156 Alleviates Mechanical Hypersensitivity in a Rat Model of Breast Cancer Induced Bone Pain. Front Pharmacol. 2018 May 15;9:495.
[2]. Mia Engstr?m, et al. Superagonism at the Human Somatostatin Receptor Subtype 4. J Pharmacol Exp Ther. 2005 Jan;312(1):332-8. |
| | J-2156 TFA Preparation Products And Raw materials |
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