|
|
| | CIPROXIFAN Basic information |
| Product Name: | CIPROXIFAN | | Synonyms: | Ciproxifan Moleate;FUB 359 Maleate;FUB359 Maleate;FUB-359 Maleate;Ciproxifan maleate, >=98%;Cyclopropyl (4-[3-(1H-imidazol-4-yl)propyloxy]phenyl) ketone maleate salt;(4-(3-(1H-Imidazol-5-yl)propoxy)phenyl)(cyclopropyl)methanone maleate;CIPROXIFAN | | CAS: | 184025-19-2 | | MF: | C16H18N2O2.C4H4O4 | | MW: | 386.402 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 184025-19-2.mol |  |
| | CIPROXIFAN Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO: soluble32mg/mL | | form | powder | | color | white to beige |
| | CIPROXIFAN Usage And Synthesis |
| Description | Ciproxifan is a histamine H3 receptor antagonist (Ki = 0.5 nM for inhibition of histamine release in rat synaptosomal preparations). It is selective for histamine H3 over histamine H1 and H2, M3 muscarinic, and α1D- and β1-adrenergic receptors (Kis = 3.15-25 μM), as well as the serotonin (5-HT) receptor subtypes 5-HT1B, 5-HT2A, 5-HT3, and 5-HT4 (Kis = 1.58-15 μM) in radioligand binding assays. Ciproxifan (3-300 nM) inhibits relaxation in precontracted isolated guinea pig ileal longitudinal muscle induced by R-(–)-α-methylhistamine . In vivo, ciproxifan reduces R-(–)-α-methylhistamine-induced water consumption in rats (ED50 = 0.09 mg/kg). It increases wake episode duration and latency to fall asleep in rats when administered at a dose of 2 mg/kg. | | Uses | Ciproxifan is a potent histamine H3 receptor antagonist which affects histamine levels in the brain. It may be used in treatments for sleep and neurological disorders. | | Biochem/physiol Actions | Potent, selective H3 histamine receptor antagonist. |
| | CIPROXIFAN Preparation Products And Raw materials |
|