| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Email: |
sales@invivochem.cn |
| Products Intro: |
Product Name:GSK-872 hydrochloride
CAS:2703752-81-0
Purity:98% HPLC Package:1mg Remarks:V41990
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| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:GSK872 HCl（1346546-69-7 free base）;GSK872 HCl（1346546697 free base）,GSK-872 HCl（1346546-69-7 free base）,GSK872 HCl（1346546 69 7 free base）
CAS:2703752-81-0
Purity:99.82% Package:1 mL;10 mg;100 mg;2 mg;25 mg;5 mg;50 mg
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| Company Name: |
Nanjing Tengyi Biotechnology Co., Ltd
|
| Tel: |
025-58851786 17714337195 |
| Email: |
sales@tybiochem.com |
| Products Intro: |
Product Name:GSK-872 hydrochloride
CAS:2703752-81-0
Purity:95+% Package:1g;5g
|
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| | GSK-872 (hydrochloride) Basic information |
| Product Name: | GSK-872 (hydrochloride) | | Synonyms: | GSK-872 (hydrochloride);GSK872 HCl（1346546-69-7 free base）;GSK872 HCl（1346546697 free base）,GSK-872 HCl（1346546-69-7 free base）,GSK872 HCl（1346546 69 7 free base） | | CAS: | 2703752-81-0 | | MF: | C19H18ClN3O2S2 | | MW: | 419.94 | | EINECS: | | | Product Categories: | | | Mol File: | 2703752-81-0.mol |  |
| | GSK-872 (hydrochloride) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO : 10 mg/mL (23.81 mM; ultrasonic and warming and heat to 60°C)| | | form | Solid | | color | Yellow to brown | | Water Solubility | Water : 2.5 mg/mL (5.95 mM; ultrasonic and warming and heat to 60°C) |
| | GSK-872 (hydrochloride) Usage And Synthesis |
| Biological Activity | GSK-872 hydrochloride is a RIPK3 inhibitor, which binds RIP3 kinase domain with an IC50 of 1.8 nM, and inhibits kinase activity with an IC50 of 1.3 nM. GSK-872 hydrochloride decreases the RIPK3-mediated necroptosis and subsequent cytoplasmic translocation and expression of HMGB1, as well as ameliorates brain edema and neurological deficits in early brain injury[1][2][3].
GSK-872 (GSK’872; 0.01-3 μM; 24 hours) blocks TNF-induced necroptosis in human HT-29 cells in a concentration-dependent manner[1].
GSK-872 hydrochloride (25 mM; intracerebroventricular injection) can attenuate brain edema and improve neurological function following subarachnoid hemorrhage (SAH) and reduce the number of necrotic cells. GSK-872 hydrochloride can also decrease the protein levels of RIPK3 and MLKL, and cytoplasmic translocation and expression of HMGB1, an important pro-inflammatory protein[3]. | | References | [1]. Mandal P, et al. RIP3 induces apoptosis independent of pronecrotic kinase activity. Mol Cell. 2014 Nov 20;56(4):481-95. [2]. Arora D, et al. Deltamethrin induced RIPK3-mediated caspase-independent non-apoptotic cell death in rat primary hepatocytes. Biochem Biophys Res Commun. 2016 Oct 14;479(2):217-223. [3]. Chen T, et al. Inhibiting of RIPK3 attenuates early brain injury following subarachnoid hemorrhage: Possibly through alleviating necroptosis. Biomed Pharmacother. 2018;107:563-570. |
| | GSK-872 (hydrochloride) Preparation Products And Raw materials |
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