Benzonitrile, 4-(2-hydroxycyclohexyl)-2-(trifluoromethyl)- manufacturers
- (rac)-PF-998425
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- $0.00 / 1gram
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2023-11-27
- CAS:1076225-26-7
- Min. Order: 1gram
- Purity: 99% HPLC
- Supply Ability: 20 tons
- PF-998425
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- $0.00 / 1kg
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2023-08-31
- CAS:1076225-26-7
- Min. Order: 1kg
- Purity: 99.9%
- Supply Ability: 20tons
- (rac)-PF-998425
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- $30.00 / 1kg
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2023-08-21
- CAS:1076225-26-7
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 1000t/year
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| Benzonitrile, 4-(2-hydroxycyclohexyl)-2-(trifluoromethyl)- Basic information |
| Benzonitrile, 4-(2-hydroxycyclohexyl)-2-(trifluoromethyl)- Chemical Properties |
Boiling point | 365.2±42.0 °C(Predicted) | density | 1.28±0.1 g/cm3(Predicted) | storage temp. | Store at -20°C | solubility | DMSO : 100 mg/mL (371.39 mM; Need ultrasonic) | pka | 14.84±0.40(Predicted) |
| Benzonitrile, 4-(2-hydroxycyclohexyl)-2-(trifluoromethyl)- Usage And Synthesis |
Biological Activity | (rac)-PF-998425 is a potent, selective, nonsteroidal androgen receptor (AR) antagonist. (rac)-PF-998425 has IC50 values of 26 and 90 nM in the AR binding and cellular assays, respectively. (rac)-PF-998425 has the potential for the research of the androgenetic alopecia[1]. | References | [1]. Li JJ, et al. Rational design and synthesis of 4-((1R,2R)-2-hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for dermatological indications. J Med Chem. 2008;51(21):7010-7014. |
| Benzonitrile, 4-(2-hydroxycyclohexyl)-2-(trifluoromethyl)- Preparation Products And Raw materials |
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