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Carbamic acid, N-[(3R)-1-[[2-[[[4-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]amino]carbonyl]-4-pyridinyl]methyl]-3-piperidinyl]-, 1,1-dimethylethyl ester

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Carbamic acid, N-[(3R)-1-[[2-[[[4-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]amino]carbonyl]-4-pyridinyl]methyl]-3-piperidinyl]-, 1,1-dimethylethyl ester Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:Carbamic acid, N-[(3R)-1-[[2-[[[4-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]amino]carbonyl]-4-pyridinyl]methyl]-3-piperidinyl]-, 1,1-dimethylethyl ester
CAS:2448173-47-3
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: Jinan Carbotang Biotech Co.,Ltd.
Tel: +8615866703830
Email: figo.gao@foxmail.com
Products Intro: Product Name:Carbamic acid, N-[(3R)-1-[[2-[[[4-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]amino]carbonyl]-4-pyridinyl]methyl]-3-piperidinyl]-, 1,1-dimethylethyl ester
CAS:2448173-47-3
Purity:98% Package:5KG;1KG
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:Menin-MLL inhibitor 20
CAS:2448173-47-3
Purity:98% Package:10mg Remarks:V2515
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354
Email: support@targetmol.com
Products Intro: Product Name:Menin-MLL inhibitor 20
CAS:2448173-47-3
Package:1 mg；1 mL * 10mM (in DMSO)；10 mg；100 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:Menin-MLL inhibitor 20
CAS:2448173-47-3
Purity:98% Package:$40.9/1mg;$167.9/5mg;$276.9/10mg;$553.9/25mg;$899.9/50mg;Bulk package Remarks:98%
Carbamic acid, N-[(3R)-1-[[2-[[[4-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]amino]carbonyl]-4-pyridinyl]methyl]-3-piperidinyl]-, 1,1-dimethylethyl ester Basic information
Product Name:Carbamic acid, N-[(3R)-1-[[2-[[[4-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]amino]carbonyl]-4-pyridinyl]methyl]-3-piperidinyl]-, 1,1-dimethylethyl ester
Synonyms:Carbamic acid, N-[(3R)-1-[[2-[[[4-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]amino]carbonyl]-4-pyridinyl]methyl]-3-piperidinyl]-, 1,1-dimethylethyl ester;Menin-MLL inhibitor 20,MRN73473;Menin-MLL inhibitor 20;Epigenetic Reader Domain,mixed-lineage,MeninMLL inhibitor 20,irreversible,leukemia,MLL,Inhibitor,antitumor,Menin MLL inhibitor 20,inhibit,Menin,Menin-MLL inhibitor 20;(R)-4-[[3-(Boc-amino)-1-piperidyl]methyl]-N-[4-(4-morpholino-7H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl]pyridine-2-carboxamide
CAS:2448173-47-3
MF:C33H40N8O4
MW:612.72
EINECS:
Product Categories:
Mol File:2448173-47-3.mol
Carbamic acid, N-[(3R)-1-[[2-[[[4-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]amino]carbonyl]-4-pyridinyl]methyl]-3-piperidinyl]-, 1,1-dimethylethyl ester Structure
Carbamic acid, N-[(3R)-1-[[2-[[[4-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]amino]carbonyl]-4-pyridinyl]methyl]-3-piperidinyl]-, 1,1-dimethylethyl ester Chemical Properties
density 1.34±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 33.33 mg/mL (54.40 mM; ultrasonic and warming and heat to 60°C)
form Solid
pka11.80±0.70(Predicted)
color Light yellow to yellow
Safety Information
MSDS Information
Carbamic acid, N-[(3R)-1-[[2-[[[4-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]amino]carbonyl]-4-pyridinyl]methyl]-3-piperidinyl]-, 1,1-dimethylethyl ester Usage And Synthesis
Biological ActivityMenin-MLL inhibitor 20 is an irreversible menin-MLL interaction inhibitor with antitumor activities (WO2020142557A1, compound 6)[1]. The Histone-lysine N-methyltransferase 2 (KMT2) family of proteins, which currently consists of at least 5 members, methylate ly sine 4 on the histone H3 tails at important regulatory regions in the genome and thereby impart crucial functions through the modulation of chromatin structures and DNA accessibility. These enzymes are known to play an important role in the regulation of gene expression during early development and hematopoiesis. The human KMT2 family was initially named the mixed-lineage leukaemia (MLL) family, owing to the role of the first-found member in this disease[1].
References[1]. Thomas Butler, et al. Irreversible inhibitors of menin-mll interaction. WO2020142557A1.
Carbamic acid, N-[(3R)-1-[[2-[[[4-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]amino]carbonyl]-4-pyridinyl]methyl]-3-piperidinyl]-, 1,1-dimethylethyl ester Preparation Products And Raw materials
Tag:Carbamic acid, N-[(3R)-1-[[2-[[[4-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]amino]carbonyl]-4-pyridinyl]methyl]-3-piperidinyl]-, 1,1-dimethylethyl ester(2448173-47-3) Related Product Information