5,6,7a,11-Tetraazacyclohepta[def]cyclopenta[a]fluoren-4(7H)-one, 2-fluoro-5,8,9,10,10a,11-hexahydro-10a-methyl-, (10aR)-, (2Z)-2-butenedioate (2:3) Suppliers list
|
Company Name: |
InvivoChem
|
Tel: |
13549236410 |
Email: |
sales@invivochem.cn |
Products Intro: |
Product Name:Pamiparib maleate CAS:2086689-94-1 Purity:98% HPLC Package:1mg Remarks:V3281
|
Company Name: |
TargetMol Chemicals Inc.
|
Tel: |
4008200310 |
Email: |
marketing@tsbiochem.com |
Products Intro: |
Product Name:Pamiparib maleate;Pamiparib maleate CAS:2086689-94-1 Purity:98% Package:5 mg
|
|
| 5,6,7a,11-Tetraazacyclohepta[def]cyclopenta[a]fluoren-4(7H)-one, 2-fluoro-5,8,9,10,10a,11-hexahydro-10a-methyl-, (10aR)-, (2Z)-2-butenedioate (2:3) Basic information |
Product Name: | 5,6,7a,11-Tetraazacyclohepta[def]cyclopenta[a]fluoren-4(7H)-one, 2-fluoro-5,8,9,10,10a,11-hexahydro-10a-methyl-, (10aR)-, (2Z)-2-butenedioate (2:3) | Synonyms: | 5,6,7a,11-Tetraazacyclohepta[def]cyclopenta[a]fluoren-4(7H)-one, 2-fluoro-5,8,9,10,10a,11-hexahydro-10a-methyl-, (10aR)-, (2Z)-2-butenedioate (2:3);Pamiparib maleate;BGB-29 maleat 0 | CAS: | 2086689-94-1 | MF: | C20H19FN4O5 | MW: | 414.39 | EINECS: | | Product Categories: | | Mol File: | 2086689-94-1.mol | ![5,6,7a,11-Tetraazacyclohepta[def]cyclopenta[a]fluoren-4(7H)-one, 2-fluoro-5,8,9,10,10a,11-hexahydro-10a-methyl-, (10aR)-, (2Z)-2-butenedioate (2:3) Structure](CAS/20211123/GIF/2086689-94-1.gif) |
| 5,6,7a,11-Tetraazacyclohepta[def]cyclopenta[a]fluoren-4(7H)-one, 2-fluoro-5,8,9,10,10a,11-hexahydro-10a-methyl-, (10aR)-, (2Z)-2-butenedioate (2:3) Chemical Properties |
| 5,6,7a,11-Tetraazacyclohepta[def]cyclopenta[a]fluoren-4(7H)-one, 2-fluoro-5,8,9,10,10a,11-hexahydro-10a-methyl-, (10aR)-, (2Z)-2-butenedioate (2:3) Usage And Synthesis |
Description | Pamiparib, also known as BGB-290, is a highly potent and selective PARP inhibitor with favorable drug metabolism and pharmacokinetic properties. BGB-290 selectively binds to PARP and prevents PARP-mediated repair of single-strand DNA breaks via the base-excision repair (BER) pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability, and eventually leads to apoptosis. BGB-290 may both potentiate the cytotoxicity of DNA-damaging agents and reverse tumor cell chemo- and radioresistance. |
| 5,6,7a,11-Tetraazacyclohepta[def]cyclopenta[a]fluoren-4(7H)-one, 2-fluoro-5,8,9,10,10a,11-hexahydro-10a-methyl-, (10aR)-, (2Z)-2-butenedioate (2:3) Preparation Products And Raw materials |
|