NETAMIFTIDE
中文名称 | NETAMIFTIDE |
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中文同义词 | NEMIFITIDE DITFA;FLUORO-PHE-HYP-ARG-GLY-TRP-NH2;五肽INN 00835 |
英文名称 | NETAMIFTIDE |
英文同义词 | Bis(trifluoroacetate);NETAMIFTIDE;(2S)-N-[(1S)-1-[[(1S)-1-[[(2S)-2-amino-3-(4-fluorophenyl)propanoyl]carbamoyl]-2-(1H-indol-3-yl)ethyl]carbamoylmethylcarbamoyl]-4-(diaminomethylideneamino)butyl]-4-hydroxy-pyrrolidine-2-carboxamide;Netamiftide ditriflutate;Nemifitide diTFA;INN 00835 diTFA;Nemifitide di;Nemifitide Ditriflutate |
CAS号 | 204992-09-6 |
分子式 | C35H44F4N10O8 |
分子量 | 808.79 |
EINECS号 | |
相关类别 | 多肽 |
Mol文件 | 204992-09-6.mol |
结构式 | ![]() |
NETAMIFTIDE 性质
储存条件 | Store at -20°C |
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形态 | 固体 |
颜色 | 白色至米白色 |
水溶解性 | Water: 250 mg/mL (270.91 mM) |
Nemifitide diTFA (INN 00835 diTFA) and its active metabolite (M1) bind at micromolar concentrations to several receptors including the 5-HT 2A , 5-HT 2C , melanocortin MC4, MC5 and bombesin.
Nemifitide diTFA (INN 00835 diTFA; 0.3 mg/kg; IP; daily; for 14 days) significantly increases swimming in the FSL rats after just 5 days of treatment and has long-lasting effect.
Nemifitide diTFA (0.0125-15.0 mg/kg) significantly increases swimming in the FSL rats at both low (0.025-0.3 mg/kg) and high (3.0-15.0 mg/kg) doses but not at intermediate (0.4-2.4 mg/kg) doses.
Animal Model: | Male Flinders Sensitive Line (FSL) rat weighing 280-320 g |
Dosage: | 0.3 mg/kg |
Administration: | IP; daily; for 14 days |
Result: | Significantly increased swimming in the FSL rats after just 5 days of treatment and had long-lasting effect. |
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/04/30 | HY-105077A | NETAMIFTIDE Nemifitide diTFA | 204992-09-6 | 5mg | 2500元 |
2024/04/30 | HY-105077A | NETAMIFTIDE Nemifitide diTFA | 204992-09-6 | 10mg | 4500元 |