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Products Intro: |
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| Clocapramine Basic information |
Product Name: | Clocapramine | Synonyms: | Clocapramine | CAS: | | MF: | | MW: | 0 | EINECS: | | Product Categories: | | Mol File: | Mol File | ![Clocapramine Structure]() |
| Clocapramine Chemical Properties |
storage temp. | Hygroscopic, Refrigerator, under inert atmosphere | solubility | DMSO (Slightly), Methanol (Very Slightly) | form | Solid | color | White to Off-White |
| Clocapramine Usage And Synthesis |
Originator | Clofekton,Yoshitomi,Japan,1974 | Uses | Clocapramine is an anti-psychotic drug. | Manufacturing Process | A mixture of 5.0 g of 3-chloro-5-(3-chloropropyl)-10,11-dihydro-5Hdibenz[b,f]azepine, 5.0 g of 4-carbamoyl-4-piperidinopiperidine and 50 ml of
dimethylformamide is heated at 100°C for 10 hours. The solvent is distilled
off. After the addition of a 2% sodium carbonate solution to the flask, the
content is scratched to yield a semisolid, which is dissolved in 50 ml of
isopropanol. A solution of 5 g of maleic acid in 50 ml of isopropanol is added,
and the precipitate is collected by filtration and recrystallized from isopropanol
to give 5.6 g of crystalline 3-chloro-5-[3-(4-carbamoyl-4-piperidinopiperidino)
propyl]-10,11-dihydro-5H-dibenz[b,f]azepine di(hydrogen maleate) with 1/2
molecule of water of crystallization melting at 181°C to 183°C. | Therapeutic Function | Neuroleptic |
| Clocapramine Preparation Products And Raw materials |
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