Company Name: |
TargetMol Chemicals Inc.
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Tel: |
15002134094 |
Email: |
marketing@targetmol.cn |
Products Intro: |
Product Name:JH-XVI-178 CAS:2648453-53-4 Purity:0 Package:25mg/RMB 9870
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| 2,8-Diazaspiro[4.5]decan-1-one, 8-[3-chloro-5-(1-methyl-1H-indazol-5-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]- Basic information |
| 2,8-Diazaspiro[4.5]decan-1-one, 8-[3-chloro-5-(1-methyl-1H-indazol-5-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]- Chemical Properties |
Boiling point | 782.1±60.0 °C(Predicted) | density | 1.60±0.1 g/cm3(Predicted) | storage temp. | Store at -20°C | pka | 9.84±0.40(Predicted) | form | Solid | color | White to off-white |
| 2,8-Diazaspiro[4.5]decan-1-one, 8-[3-chloro-5-(1-methyl-1H-indazol-5-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]- Usage And Synthesis |
Biological Activity | JH-XVI-178 is a highly potent and selective inhibitor of CDK8/19 that displays low clearance and moderate oral pharmacokinetic properties. | References | [1]. Hatcher JM, et al. Development of Highly Potent and Selective Pyrazolopyridine Inhibitor of CDK8/19. ACS Med Chem Lett. 2021 Oct 22;12(11):1689-1693. |
| 2,8-Diazaspiro[4.5]decan-1-one, 8-[3-chloro-5-(1-methyl-1H-indazol-5-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]- Preparation Products And Raw materials |
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