| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:DDD107498 succinate;DDD107498 succinate
CAS:2444781-71-7
Purity:100% Package:100 mg;200 mg;50 mg
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| Company Name: |
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd
|
| Tel: |
021-59167510 18117107507 |
| Email: |
vip@med-life.cn |
| Products Intro: |
Product Name:Cabamiquine succinate
CAS:2444781-71-7
Purity:>=99% Package:5mg;50mg;200mg;10mM*1mLinDMSO;25mg;10mg;100mg
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| Company Name: |
RD International Technology Co., Limited
|
| Tel: |
18024082417 |
| Email: |
market@ubiochem.com |
| Products Intro: |
Product Name:Cabamiquine succinate
CAS:2444781-71-7
Purity:5mg;10mg;50mg;100mg;250mg;500mg;1g Package:5mg;10mg;50mg;100mg;250mg;500mg;1g
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| | Butanedioic acid, compd. with 6-fluoro-2-[4-(4-morpholinylmethyl)phenyl]-N-[2-(1-pyrrolidinyl)ethyl]-4-quinolinecarboxamide (1:1) Basic information |
| | Butanedioic acid, compd. with 6-fluoro-2-[4-(4-morpholinylmethyl)phenyl]-N-[2-(1-pyrrolidinyl)ethyl]-4-quinolinecarboxamide (1:1) Chemical Properties |
| storage temp. | 4°C, away from moisture and light | | solubility | DMSO: 135 mg/mL (232.50 mM) | | form | Solid | | color | White to off-white |
| | Butanedioic acid, compd. with 6-fluoro-2-[4-(4-morpholinylmethyl)phenyl]-N-[2-(1-pyrrolidinyl)ethyl]-4-quinolinecarboxamide (1:1) Usage And Synthesis |
| Description | DDD107498 succinate (DDD-498 succinate) is a potent and orally active antimalarial agent, inhibits multiple life-cycle stages of the parasite, with an EC50 of 1 nM against P. falciparum 3D7. DDD107498 succinate inhibits protein synthesis by targeting eEF2/CaMKIII, with an EC50 of 2 nM for WT-PfeEF2[1].
EC50: 1 nM (3D7 parasites), 2 nM (WT-PfeEF2)[1] DDD107498 exhibits an ED90 of 0.57 mg/kg after a single oral dose in mice infected with the rodent parasite P. berghei[1]. | | References | [1]. BaragaÑa B, et al. A novel multiple-stage antimalarial agent that inhibits protein synthesis. Nature. 2015 Jun 18;522(7556):315-20. |
| | Butanedioic acid, compd. with 6-fluoro-2-[4-(4-morpholinylmethyl)phenyl]-N-[2-(1-pyrrolidinyl)ethyl]-4-quinolinecarboxamide (1:1) Preparation Products And Raw materials |
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