ABAPERIDONE
| 中文名称 | ABAPERIDONE |
|---|---|
| 中文同义词 | 阿巴哌酮;化合物 T14083 |
| 英文名称 | ABAPERIDONE |
| 英文同义词 | ABAPERIDONE;4H-1-Benzopyran-4-one, 7-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-(hydroxymethyl)- |
| CAS号 | 183849-43-6 |
| 分子式 | C25H25FN2O5 |
| 分子量 | 452.47 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 183849-43-6.mol |
| 结构式 |  |
ABAPERIDONE 性质
| 沸点 | 667.3±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.320±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 13.48±0.10(Predicted) |
|
D 2 Receptor 17 nM (IC 50 ) |
5-HT 2A Receptor 6.2 nM (IC 50 ) |
Abaperidone possesses good affinity for dopamine D 2 receptors, together with a greater affinity for 5-HT 2 receptors with IC 50 of 17 and 6.2 nM, reaspectively.
The time course of the inhibition of climbing behavior for a period of several hours after oral administration of either 0.5 mg/kg of Abaperidone or risperidone is tested in mice. Also is included a comparative test of catalepsy induced by Abaperidone and risperidone along several hours following oral administration at several doses in rats. A somewhat lesser induction of catalepsy is observed for Abaperidone. A study of serum prolactin levels after oral administration of Abaperidone, haloperidol, and risperidone at 5 mg/kg for either 1 or 3 days in rats. Increases in prolactin levels after oral administration of Abaperidone are smaller than those for reference drugs.