CS-1374
| 中文名称 | CS-1374 |
|---|---|
| 中文同义词 | |
| 英文名称 | Cryptophycin |
| 英文同义词 | Cryptophycin;cryptophycin 1;CS-1374;Cyclo[(2R)-2-methyl-β-alanyl-(2S)-2-hydroxy-4-methylpentanoyl-(2E,5S,6S)-5-hydroxy-6-[(2R,3R)-3-phenyl-2-oxiranyl]-2-heptenoyl-3-chloro-O-methyl-D-tyrosyl] |
| CAS号 | 124689-65-2 |
| 分子式 | C35H43ClN2O8 |
| 分子量 | 655.19 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 124689-65-2.mol |
| 结构式 |  |
CS-1374 性质
| 比旋光度 | White or light colored glassy solid. D +33.8° (c = 1.83 in methanol) |
|---|---|
| 沸点 | 889.4±65.0 °C(Predicted) |
| 密度 | 1.171±0.06 g/cm3(Predicted) |
| 酸度系数(pKa) | 12.83±0.70(Predicted) |
Cryptophycin 1 是一种从 Nostoc sp. 中分离出来的有效的细胞毒性抗微管剂。Cryptophycin 1 可以诱导细胞凋亡，并具有抗肿瘤活性和出色的抗增殖能力。
Cryptophycin 1 (50 pM) rapidly causes morphological changes consistent with the induction of apoptosis in SKOV3 and MDA-MB-435 cells.
Cryptophycin 1 (50 pM; 12-24 h) causes an accumulation of MDA-MB-435 cells in G2/M.
Cryptophycin 1 (100 nM; 1-7 min) markedly reduces the rates and extents of microtubule shortening and growing events and dramatically increases the duration of phases of attenuation or pause.
Apoptosis Analysis
| Cell Line: | SKOV3 cells |
| Concentration: | 50 pM |
| Incubation Time: | 4 hours |
| Result: | Caused rapid cell shrinkage, loss of the normal elliptical spheroid shape and the formation of membrane blebs. |
Cell Cycle Analysis
| Cell Line: | MDA-MB-435 cells |
| Concentration: | 50 pM |
| Incubation Time: | 12, 18, 24 hours |
| Result: |
A doubling in the number of cells in G
2
/M at 12 hr.
Still a large number of cells (58%) in G 2 /M at 18 hr. |
Cryptophycin 1 (i.v.) exhibits anti-tumor activity in mice.
安全信息
| 危险品运输编号 | 3172 |
|---|---|
| 危险等级 | 6.1(b) |
| 包装类别 | III |