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β-Alanine, N-[2-(5-fluoro-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-, (1R)-1-[(2R,3S)-2-(carboxymethyl)-1-[[(2-methylphenyl)amino]carbonyl]-4-oxo-3-azetidinyl]ethyl ester

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β-Alanine, N-[2-(5-fluoro-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-, (1R)-1-[(2R,3S)-2-(carboxymethyl)-1-[[(2-methylphenyl)amino]carbonyl]-4-oxo-3-azetidinyl]ethyl ester Suppliers list
Company Name: Aladdin Scientific
Tel:
Email: tp@aladdinsci.com
Products Intro: Product Name:α5β1integrin agonist-1
CAS:2756557-83-0
Purity:99% Package:$340.9/1mg;$850.9/5mg;$1450.9/10mg;Bulk package Remarks:99%
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:α5β1 integrin agonist-1
CAS:2756557-83-0
Package:25mg/RMB 10600;100mg/RMB 17500;50mg/RMB 13800
Company Name: Biorbyt Ltd.  
Tel: +44 (0)1223 859 353
Email: info@biorbyt.com
Products Intro: Product Name:α5β1 integrin agonist-1
CAS:2756557-83-0
β-Alanine, N-[2-(5-fluoro-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-, (1R)-1-[(2R,3S)-2-(carboxymethyl)-1-[[(2-methylphenyl)amino]carbonyl]-4-oxo-3-azetidinyl]ethyl ester Basic information
Product Name:β-Alanine, N-[2-(5-fluoro-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-, (1R)-1-[(2R,3S)-2-(carboxymethyl)-1-[[(2-methylphenyl)amino]carbonyl]-4-oxo-3-azetidinyl]ethyl ester
Synonyms:β-Alanine, N-[2-(5-fluoro-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-, (1R)-1-[(2R,3S)-2-(carboxymethyl)-1-[[(2-methylphenyl)amino]carbonyl]-4-oxo-3-azetidinyl]ethyl ester
CAS:2756557-83-0
MF:C24H26FN5O9
MW:547.49
EINECS:
Product Categories:
Mol File:2756557-83-0.mol
β-Alanine, N-[2-(5-fluoro-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-, (1R)-1-[(2R,3S)-2-(carboxymethyl)-1-[[(2-methylphenyl)amino]carbonyl]-4-oxo-3-azetidinyl]ethyl ester Structure
β-Alanine, N-[2-(5-fluoro-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-, (1R)-1-[(2R,3S)-2-(carboxymethyl)-1-[[(2-methylphenyl)amino]carbonyl]-4-oxo-3-azetidinyl]ethyl ester Chemical Properties
density 1.51±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 100 mg/mL (182.65 mM; Need ultrasonic)
form Solid
pka4.20±0.10(Predicted)
color White to off-white
Safety Information
MSDS Information
β-Alanine, N-[2-(5-fluoro-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-, (1R)-1-[(2R,3S)-2-(carboxymethyl)-1-[[(2-methylphenyl)amino]carbonyl]-4-oxo-3-azetidinyl]ethyl ester Usage And Synthesis
Usesα5β1?integrin agonist-1, acting as α5β1 integrin agonist, is able to selectively deliver 5-FU into tumor cells, successfully leading to cancer cell death.
References[1] Baiula M, et al. Selective Integrin Ligands Promote Cell Internalization of the Antineoplastic Agent Fluorouracil. ACS Pharmacol Transl Sci. 2021 Sep 2;4(5):1528-1542. DOI:10.1021/acsptsci.1c00094
β-Alanine, N-[2-(5-fluoro-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-, (1R)-1-[(2R,3S)-2-(carboxymethyl)-1-[[(2-methylphenyl)amino]carbonyl]-4-oxo-3-azetidinyl]ethyl ester Preparation Products And Raw materials
Tag:β-Alanine, N-[2-(5-fluoro-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-, (1R)-1-[(2R,3S)-2-(carboxymethyl)-1-[[(2-methylphenyl)amino]carbonyl]-4-oxo-3-azetidinyl]ethyl ester(2756557-83-0) Related Product Information
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