SB 223412 manufacturers
- Talnetant
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- $1.00 / 1KG
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2020-01-02
- CAS:174636-32-9
- Min. Order: 1KG
- Purity: Min98% HPLC
- Supply Ability: g/kg/ton
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| | SB 223412 Basic information |
| Product Name: | SB 223412 | | Synonyms: | SB 223412;3-hydroxy-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide;(-)-(S)-N-(alpha-ethylbenzyl)-3-hydroxy-2-phenylquinoline-4-carboxaMide;TALNETANT//SB223412//3-hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxaMide;(-)-3-Hydroxy-2-phenyl-N-[1(S)-phenylpropyl]quinoline-4-carboxamide;(S)-N-(1-Phenylpropyl)-3-hydroxy-2-phenylquinoline-4-carboxamide;3-hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxamide;3-Hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecarboxamide | | CAS: | 174636-32-9 | | MF: | C25H22N2O2 | | MW: | 382.45 | | EINECS: | | | Product Categories: | | | Mol File: | 174636-32-9.mol |  |
| | SB 223412 Chemical Properties |
| Melting point | 125.1-126.2℃ | | Boiling point | 580.4±50.0 °C(Predicted) | | density | 1.212±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,2-8°C | | solubility | DMSO: soluble25mg/mL, clear | | form | powder | | pka | 6.70±0.50(Predicted) | | color | white to beige | | optical activity | [α]/D -25 to -31°, c = 0.5 in methanol |
| Hazard Codes | T | | Risk Statements | 25 | | Safety Statements | 45 | | RIDADR | UN 2811 6.1 / PGIII |
| | SB 223412 Usage And Synthesis |
| Description | Talnetant is an antagonist of the neurokinin-3 (NK3) receptor (Ki = 1 nM). It is selective for NK3 over NK1 and NK2 receptors (Kis = 144 and >100,000 nM, respectively, in CHO cells expressing recombinant human receptors). Talnetant inhibits calcium mobilization induced by neurokinin B in HEK293 cells expressing human NK3 receptors (IC50 = 16.6 nM). It inhibits contractions induced by the NK3 receptor agonist senktide in isolated rabbit iris sphincter muscle (pD2 = 9.1). Talnetant (5-20 mg/kg) reduces senktide-induced head shakes and tail whips in mice. It also inhibits senktide-induced wet-dog shakes, increases extracellular dopamine and norepinephrine in the medial prefrontal cortex, and attenuates haloperidol-induced increases in nucleus accumbens dopamine levels in guinea pigs. | | Uses | Talnetant acts as a neurokinin 3 (NK3) receptor antagonist used as an antispychotic. |
| | SB 223412 Preparation Products And Raw materials |
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