3-(3-pyridinyl)-1H,3H-pyrrolo(1,2-c)thiazole-7-carboxamide
| 中文名称 | 3-(3-pyridinyl)-1H,3H-pyrrolo(1,2-c)thiazole-7-carboxamide |
|---|---|
| 中文同义词 | 化合物 T10159;化合物48740 RP |
| 英文名称 | 3-(3-pyridinyl)-1H,3H-pyrrolo(1,2-c)thiazole-7-carboxamide |
| 英文同义词 | 3-(3-pyridinyl)-1H,3H-pyrrolo(1,2-c)thiazole-7-carboxamide;3-(3-Pyridinyl)-1H-pyrrolo[1,2-c]thiazole-7-carboxamide;RP-48740;1H,3H-Pyrrolo(1,2-C)thiazole-7-carboxamide, 3-(3-pyridinyl)-;48740 Rp;48740Rp;Rp 55779 |
| CAS号 | 93363-11-2 |
| 分子式 | C12H11N3OS |
| 分子量 | 245.3 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 93363-11-2.mol |
| 结构式 |  |
3-(3-pyridinyl)-1H,3H-pyrrolo(1,2-c)thiazole-7-carboxamide 性质
| 沸点 | 516.4±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.49±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 16.43±0.40(Predicted) |
48740 RP (RP-55778) 是一种血小板激活因子 (PAF) 拮抗剂。
PAF
48740 RP (RP-55778) is a platelet-activating factor (PAF) antagonist. In animals treated with 48740 RP only, the number of platelets is increased at a time corresponding to 2 and 4 h after the exposure to lipopolysaccharide (LPS) and the number of eosinophils is also slightly increased. Treatment with 48740 RP in combination with the LPS exposure does not influence the increase in neutrophils seen 2 and 4 h after exposure. At 24 h the increase in the number of neutrophils is about half that in control animals. No effects are found on the LPS-induced increase in number of platelets. In animals pretreated with 48740 RP, there is a significant reduction in capillary permeability.