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| | DCPT1061 Basic information |
| | DCPT1061 Chemical Properties |
| Boiling point | 399.0±42.0 °C(Predicted) | | density | 1.201±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | | pka | 10.07±0.10(Predicted) | | form | Liquid | | color | Colorless to light yellow |
| | DCPT1061 Usage And Synthesis |
| Uses | DCPT1061 potently inhibits PRMT1, PRMT6 and PRMT8 in vitro with less inhibitory effect on PRMT3, PRMT4, and PRMT5 or other epigenetic enzymes. DCPT1061 has antitumor effect[1][2]. | | References | [1] Jianfeng Wang, et al. PRMT1 is a novel molecular therapeutic target for clear cell renal cell carcinoma. Theranostics. 2021 Mar 12;11(11):5387-5403. DOI:10.7150/thno.42345
[2] Hongru Tao, et al. PRMT1 inhibition activates the interferon pathway to potentiate antitumor immunity and enhance checkpoint blockade efficacy in melanoma. Cancer Res. 2023 Nov 22. DOI:10.1158/0008-5472.CAN-23-1082 |
| | DCPT1061 Preparation Products And Raw materials |
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