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| (2R)-1-[[chloro-(1-oxidopyridin-5-yl)methylidene]amino]oxy-3-(1-piperidyl)propan-2-ol Basic information |
Product Name: | (2R)-1-[[chloro-(1-oxidopyridin-5-yl)methylidene]amino]oxy-3-(1-piperidyl)propan-2-ol | Synonyms: | (2R)-1-[[chloro-(1-oxidopyridin-5-yl)methylidene]amino]oxy-3-(1-piperidyl)propan-2-ol;arimoclomol;Amrioclomol;Pefcalcitol;(2R-)Arimoclomol NEW;BRX-220 free base;3-Pyridinecarboximidoyl chloride, N-[(2R)-2-hydroxy-3-(1-piperidinyl)propoxy]-, 1-oxide;aggregation,Heat shock proteins,HSP,co-inducer,system,BRX220,motor,Arimoclomol,inhibit,ubiquitin,BRX 220,neurons,misfolded,proteasome,BRX-220,protein,assemblies,clearance,Inhibitor | CAS: | 289893-25-0 | MF: | C14H20ClN3O3 | MW: | 313.78 | EINECS: | | Product Categories: | | Mol File: | 289893-25-0.mol | ![(2R)-1-[[chloro-(1-oxidopyridin-5-yl)methylidene]amino]oxy-3-(1-piperidyl)propan-2-ol Structure](CAS/GIF/289893-25-0.gif) |
| (2R)-1-[[chloro-(1-oxidopyridin-5-yl)methylidene]amino]oxy-3-(1-piperidyl)propan-2-ol Chemical Properties |
Melting point | 93 - 95o C | Boiling point | 539.2±60.0 °C(Predicted) | density | 1.32±0.1 g/cm3(Predicted) | storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere | solubility | Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly) | form | Solid | pka | 14.03±0.20(Predicted) | color | White to Off-White | Stability: | Hygroscopic |
| (2R)-1-[[chloro-(1-oxidopyridin-5-yl)methylidene]amino]oxy-3-(1-piperidyl)propan-2-ol Usage And Synthesis |
Uses | Arimoclomol is a co-inducer of HSP that acts through heat shock factor 1 (HSF1) in cells undergoing cellular stress. Has therapeutic potential in motor neuron degenerative diseases. Potential treatment for liposomal storage disorders, such as Niemann-Pick disease type C. |
| (2R)-1-[[chloro-(1-oxidopyridin-5-yl)methylidene]amino]oxy-3-(1-piperidyl)propan-2-ol Preparation Products And Raw materials |
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