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| | derquantel Basic information |
| Product Name: | derquantel | | Synonyms: | derquantel;2-Deoxoparaherquamide;Unii-0L0ugk6oox;2-DeoxoparaherquaMide, 2-DeoxoparaherquaMide A, 2-DesoxoparaherquaMide A, PF 00520904, PNU 141962;Spiro[4H,8H-[1,4]dioxepino[2,3-g]indole-8,7'(8'H)-[5H,6H-5a,9a](iminomethano)[1H]cyclopent[f]indolizin]-10'-one, 2',3',8'a,9,9',10-hexahydro-1'-hydroxy-1',4,4,8',8',11'-hexamethyl-, (1'R,5'aS,7'R,8'aS,9'aR)- | | CAS: | 187865-22-1 | | MF: | C28H37N3O4 | | MW: | 479.61 | | EINECS: | | | Product Categories: | | | Mol File: | 187865-22-1.mol |  |
| | derquantel Chemical Properties |
| Boiling point | 641.3±55.0 °C(Predicted) | | density | 1.34 | | storage temp. | Store at -20°C | | solubility | DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble | | form | A solid | | pka | 15.18±0.60(Predicted) | | color | White to off-white | | JECFA Number | 75 |
| | derquantel Usage And Synthesis |
| Description | Derquantel is an anthelmintic spiroindole that acts as a nicotinic acetylcholine receptor antagonist, causing flaccid paralysis and expulsion of nematodes. A combination of derquantel and the macrocyclic lactone, abamectin , has been found to have synergistic anthelmintic effects against gastrointestinal nematode parasites in sheep. | | Uses | Derquantel is a semi-synthetic paraherquamide analogue prepared by removal of the 2-oxo group in a four-step sequence of N-protection, reduction, N-deprotection and a final reduction. Derquantel isa potent nematocide and was the first paraherquamide to be successfully commercialised in combination with avermectin. Derquantel, like other paraherquamides, induces a flaccid paralysis in nematodes thought to be due to inhibition of nicotinic acetylcholine receptors acting as an antagonist of acetylcholine. | | Definition | ChEBI: Derquantel is an azaspiro compound. |
| | derquantel Preparation Products And Raw materials |
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