| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:Anti-INCENP
Purity:IgG fraction of antiserum, buffered aqueous solution Package:200μL Remarks:I5283
|
|
| | ANTI-INCENP Basic information |
| Product Name: | ANTI-INCENP | | Synonyms: | ANTI-INNER CENTROMERE PROTEIN;ANTI-INCENP;Anti-INCENP antibody produced in rabbit | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![ANTI-INCENP Structure]() |
| | ANTI-INCENP Chemical Properties |
| storage temp. | -20°C | | form | buffered aqueous solution |
| | ANTI-INCENP Usage And Synthesis |
| Uses | Anti-INCENP antibody produced in rabbit has been used in western blotting and immunofluorescence. | | General Description | The gene INCENP (inner centromere protein) encodes an inner centromere protein that forms a component of the chromosomal passenger complex (CPC). It is found to be localized to inner centromeres during mitosis. The CPC also contains Aurora B, survivin, and Borealin. | | Biochem/physiol Actions | The inner centromere protein encoded by the INCENP gene is phosphorylated by Cdk1 (cyclin dependent kinase 1) in mitosis. It is found to be associated with Plk1 (Polo-like kinase) in a polo-box–dependent manner. Plk1 is a serine/threonine kinase that functions in cell cycle, especially in mitosis. INCEP participates in the localization of Bub1 (Budding uninhibited by benzimidazole 1), a serine/threonine kinase involved in spindle checkpoint, to kinetochore. This, in turn, promotes the recruitment of Plk1 to kinetochores. Phosphorylated INCENP stimulates the activity of Aurora B kinase at centromeres and the central spindle that is important for chromosome segregation and cytokinesis, respectively. |
| | ANTI-INCENP Preparation Products And Raw materials |
|