化合物 T11797
| 中文名称 | 化合物 T11797 |
|---|---|
| 中文同义词 | 化合物 T11797 |
| 英文名称 | 1-[(4-HYDROXYPHENOXY)ETHYLIDENE]BIS[PHOSPHINYLIDYNEBIS(OXYMETHYLENE)]-2,2-DIMETHYLPROPANOATE |
| 英文同义词 | 1-[(4-HYDROXYPHENOXY)ETHYLIDENE]BIS[PHOSPHINYLIDYNEBIS(OXYMETHYLENE)]-2,2-DIMETHYLPROPANOATE;L-690,488;Propanoic acid, 2,2-dimethyl-, [1-(4-hydroxyphenoxy)ethylidene]bis[phosphinylidynebis(oxymethylene)] ester (9CI);L 690488,L690488 |
| CAS号 | 142523-14-6 |
| 分子式 | C32H52O16P2 |
| 分子量 | 754.69 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 142523-14-6.mol |
| 结构式 |  |
化合物 T11797 性质
| 沸点 | 754.8±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.232±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -80°C |
| 酸度系数(pKa) | 9.55±0.15(Predicted) |
Inositol monophosphatase (IMPase)
The effects of L-690488 are studied in cholinergically (carbachol)-stimulated rat cortical slices and Chinese hamster ovary cells stably transfected with the human muscarinic m1 receptor (m1 CHO cells). The EC
50
values of L-690488 are 3.7 μM and 1.0 μM in rat cortical slices and m1 CHO cells, respectively). The time course and maximum accumulation of [
3
H] CMP-PA in L-690488-treated m1 CHO cells is similar to lithium but L-690488 is again much more potent (EC
50
values of 3.5 μM and 0.52 mM for L-690488 and lithium, respectively).
L-690488 attenuates the carbachol-induced elevation of inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate in m1 CHO cells. That these effects of L-690488 on the phosphatidylinositol (Pl) cycle are indeed due to inositol depletion.