EHNA
| 中文名称 | EHNA |
|---|---|
| 中文同义词 | 外消旋-9-(2-羟基-3-壬基)腺嘌呤盐酸盐;化合物 T11168 |
| 英文名称 | erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride, erythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochloride |
| 英文同义词 | erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride, erythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochloride;erythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochloride;rac erythro-9-(2-Hydroxy-3-nonyl)adenine Hydrochloride Salt;erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride, erythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochloride |
| CAS号 | 58337-38-5 |
| 分子式 | C14H24ClN5O |
| 分子量 | 313.82626 |
| EINECS号 | |
| 相关类别 | Selective inhibitor of cGMP-stimulated phosphodiesterase.;Inhibitors, Nucleotides, Bases & Related Reagents |
| Mol文件 | 58337-38-5.mol |
| 结构式 |  |
EHNA 性质
| 熔点 | 163-180°C |
|---|---|
| 储存条件 | 2-8°C |
| 溶解度 | 二甲基亚砜：>10mg/mL |
| 形态 | 固体 |
| 颜色 | 灰白色至米色 |
EHNA hydrochloride 是一个强有力的和选择性的环核苷酸磷酸二酯酶 2 (PDE2) (IC50=4 μM) 和腺苷脱氨酶 (ADA) 的双重抑制剂。EHNA hydrochloride 浓度依耐性抑制 cGMP 刺激的 PDE2 的活性，IC50 值分别为 0.8 μM (人类) 和 2 μM (猪心肌)，但是对没有刺激的 PDE2 抑制力较小。EHNA hydrochloride 在调节多种药理反应中发挥作用，包括抗病毒、抗肿瘤和抗心律失常作用。
|
hPDE2A 0.8 μM (IC 50 ) |
EHNA completely ablates the ability of cyclic GMP to activate PDE2 activity, whilst having a much smaller inhibitory effect on the unstimulated PDE2 activity.EHNA exhibits normal Michaelian kinetics of inhibition for the cyclic GMP-stimulated PDE2 activity with Hill plots near unity.EHNA prevents dAdo degradation and increases mitochondrial dATP levels in fibroblasts.
安全信息
| WGK Germany | 3 |
|---|