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Product Name:10-(1,3-Benzodioxol-5-yl)furo[3',4':6,7]naphtho[1,2-d]-1,3-dioxol-7(9H)-one
CAS:18920-47-3
Purity:0.98 Package:1g; 5g; 10g; 25g; 50g; 100g; 500g
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| | 10-(1,3-Benzodioxol-5-yl)furo[3',4':6,7]naphtho[1,2-d]-1,3-dioxol-7(9H)-one Basic information |
| Product Name: | 10-(1,3-Benzodioxol-5-yl)furo[3',4':6,7]naphtho[1,2-d]-1,3-dioxol-7(9H)-one | | Synonyms: | 10-(1,3-Benzodioxol-5-yl)furo[3',4':6,7]naphtho[1,2-d]-1,3-dioxol-7(9H)-one;Helioxanthin;ACH126447;CS-1215;Helioxanthin, ACH 126447;Furo[3',4':6,7]naphtho[1,2-d]-1,3-dioxol-7(9H)-one, 10-(1,3-benzodioxol-5-yl)- | | CAS: | 18920-47-3 | | MF: | C20H12O6 | | MW: | 348.31 | | EINECS: | | | Product Categories: | | | Mol File: | 18920-47-3.mol | ![10-(1,3-Benzodioxol-5-yl)furo[3',4':6,7]naphtho[1,2-d]-1,3-dioxol-7(9H)-one Structure](CAS/GIF/18920-47-3.gif) |
| | 10-(1,3-Benzodioxol-5-yl)furo[3',4':6,7]naphtho[1,2-d]-1,3-dioxol-7(9H)-one Chemical Properties |
| Melting point | 240-241 °C | | Boiling point | 622.5±55.0 °C(Predicted) | | density | 1.528±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Powder | | color | Light yellow to yellow |
| | 10-(1,3-Benzodioxol-5-yl)furo[3',4':6,7]naphtho[1,2-d]-1,3-dioxol-7(9H)-one Usage And Synthesis |
| Definition | ChEBI: Helioxanthin is a furonaphthodioxole that is furo[3',4':6,7]naphtho[1,2-d][1,3]dioxol-7(9H)-one substituted by a 1,3-benzodioxol-5-yl group at posiiton 10. It is a inhibitor of HBV, HCV and HSV-1 viruses. It has a role as an anti-HBV agent, a plant metabolite and an antineoplastic agent. It is a member of benzodioxoles, a furonaphthodioxole and a lignan. | | Biological Activity | helioxanthin (ach126447) is a novel inhibitor of hbv, hcv and hsv-1 virus with ec50 values of 1 μm, 3 μm and 2 μm, respectively [1].helioxanthin has shown significant antiviral effect on hbv, hcv and hsv-1 virus in vitro with ec50 values of 1 μm, 3 μm and 2 μm, respectively. in a cell culture model, the level of hbv rna, the expression of hbv antigen and its replication were all reduced by helioxanthin. besides, helioxanthin has been exhibited to have a low cytotoxicity on both mt-223 and cem24 cell lines with id50 values of 2.5 μm and 31 μm, respectively [1]. | | references | [1] yeo h1, li y, fu l, zhu jl, gullen ea, dutschman ge, lee y, chung r, huang es, austin dj, cheng yc. synthesis and antiviral activity of helioxanthin analogues. j med chem. 2005 jan 27;48(2):534-46. |
| | 10-(1,3-Benzodioxol-5-yl)furo[3',4':6,7]naphtho[1,2-d]-1,3-dioxol-7(9H)-one Preparation Products And Raw materials |
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