| Company Name: |
Wuhan Yanzhe Technology Co., Ltd
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| Tel: |
15527250409 |
| Email: |
wenhaotian12@163.com |
| Products Intro: |
Product Name:AR-A014418
Purity:98% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;76g;
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| Company Name: |
bioleaper
|
| Tel: |
18601717983 |
| Email: |
guojing@bioleaper.com |
| Products Intro: |
Product Name:AR-A014418
Purity:5mg Package:5mg Remarks:-20℃
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| | AR-A014418 Basic information |
| Product Name: | AR-A014418 | | Synonyms: | AR-A014418;GSK-3BETA INHIBITOR VIII;N-(4-METHOXYBENZYL)-N'-(5-NITRO-1,3-THIAZOL-2-YL)UREA | | CAS: | | | MF: | C12H12N4O4S | | MW: | 308.31 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | AR-A014418 Chemical Properties |
| | AR-A014418 Usage And Synthesis |
| Enzyme inhibitor | This ATP-competitive protein kinase inhibitor (FW = 308.31 g/mol; CAS
487021-52-3; Solubility: 62 mg/mL DMSO; <1 mg/mL H2O) selectively
targets glycogen synthase kinase 3β (GSK3β),with IC50 = 104 nM; Ki = 38
nM. Attesting to its high specificity for GSK3, AR-A014418 does not
significantly inhibit Cdk2 or Cdk5 (IC50 > 100 μM) or 26 other kinases.
AR-A014418 inhibits phosphorylation of the microtubule-associated
protein Tau at Ser-396 (i.e., the GSK3-specific site) in cells stably
expressing human four-repeat Tau. AR-A014418 protects N2A
neuroblastoma cells against cell death mediated by inhibition of the
phosphatidylinositol 3-kinase/protein kinase B survival pathway. AR-
A014418 inhibits neurodegeneration mediated by b-amyloid peptide in
hippocampal slices. Treatment of neuroblastoma cell lines with AR-
A014418 reduced the level of GSK-3α phosphorylation at Tyr-279
compared to GSK-3β phosphorylation at Tyr-216, and attenuated growth
via the maintenance of apoptosis.. AR-A014418-dependent
antinociceptive effects are induced by modulation of the glutamatergic
system through metabotropic and ionotropic (NMDA) receptors and the
inhibition of TNF-α and IL-1β cytokine signaling. |
| | AR-A014418 Preparation Products And Raw materials |
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