基本信息
| 中文名称 | 2,3,4,9-Tetrahydro-1-(trichloromethyl)-1H-pyrido[3,4-b]indole |
|---|---|
| 中文同义词 | |
| 英文名称 | 2,3,4,9-Tetrahydro-1-(trichloromethyl)-1H-pyrido[3,4-b]indole |
| 英文同义词 | 1-(Trichloromethyl)-1,2,3,4-tetrahydro-β-carboline;1,2,3,4-Tetrahydro-1-(trichloromethyl)-β-carboline;2,3,4,9-Tetrahydro-1-(trichloromethyl)-1H-pyrido[3,4-b]indole;TaClo;rac 1-TrichloroMethyl-1,2,3,4-Tetrahydro-β-carboline;1H-Pyrido[3,4-b]indole, 2,3,4,9-tetrahydro-1-(trichloromethyl)- |
| CAS号 | 6649-90-7 |
| 分子式 | C12H11Cl3N2 |
| 分子量 | 289.59 |
| EINECS号 | |
| 相关类别 | Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals;Aromatics;Heterocycles |
| Mol文件 | 6649-90-7.mol |
| 结构式 | ![2,3,4,9-Tetrahydro-1-(trichloromethyl)-1H-pyrido[3,4-b]indole 结构式](CAS/GIF/6649-90-7.gif) |
2,3,4,9-Tetrahydro-1-(trichloromethyl)-1H-pyrido[3,4-b]indole 性质
| 熔点 | >132°C (dec.) |
|---|---|
| 沸点 | 447.4±40.0 °C(Predicted) |
| 密度 | 1.480±0.06 g/cm3(Predicted) |
| 储存条件 | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| 溶解度 | 可溶于乙酸乙酯（少许）、甲醇（少许） |
| 酸度系数(pKa) | 16.74±0.40(Predicted) |
| 形态 | 固体 |
| 颜色 | 米色 |
用途
1-Trichloromethyl-1,2,3,4-Tetrahydro-β-carboline (TaClo) is a dopaminergic and serotonergic neurotoxin. Liver enzymes produces TaClo via catalysis reaction of Tricloroethane with Tryptamine (T894600).
TaClo destroys dopamine-producing cells and is structurally similar to the dopaminergic neurotoxin MPTP. As a result, TaClo is a molecule of importance in the study of Parkinson鈥檚 disease.