Company Name: |
Hubei Jusheng Technology Co.,Ltd. |
Tel: |
18871490254 |
Email: |
linda@hubeijusheng.com |
Products Intro: |
Product Name:(3S,4R,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6,7,7,7-tetradeuterio-6-(trideuteriomethyl)heptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,4-diol CAS:1246302-80-6 Purity:0.99 Package:5KG;1KG Remarks:C27H39D7O2
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Company Name: |
J & K SCIENTIFIC LTD.
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Tel: |
010-82848833 400-666-7788 |
Email: |
jkinfo@jkchemical.com |
Products Intro: |
Product Name:4β-Hydroxy Cholesterol-d7 CAS:1246302-80-6 Package:10Mg,1Mg
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| 4-Hydroxy Cholesterol-d7 Basic information |
Product Name: | 4-Hydroxy Cholesterol-d7 | Synonyms: | 4-Hydroxy Cholesterol-d7;CHOLEST-5-ENE-3,4-DIOL-D7;4-HYDROXYCHOLESTEROL-D7;4-beta-Hydroxy Cholesterol-d7;cholest-5-ene-3,4-diol-d7;(3S,4R,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6,7,7,7-tetradeuterio-6-(trideuteriomethyl)heptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,4-diol;4β-Hydroxy Cholesterol-d7;2H7]-4β-Hydroxycholesterol | CAS: | 1246302-80-6 | MF: | C27H46O2 | MW: | 402.65294 | EINECS: | | Product Categories: | Intermediates & Fine Chemicals;Isotope Labelled Compounds;Metabolites & Impurities;Pharmaceuticals;Steroids;Isotope Labelled Compounds, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals, Steroids | Mol File: | 1246302-80-6.mol | |
| 4-Hydroxy Cholesterol-d7 Chemical Properties |
Melting point | 154-159°C | storage temp. | -20°C | solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly, Heated) | form | Solid | color | White to Off-White |
| 4-Hydroxy Cholesterol-d7 Usage And Synthesis |
Chemical Properties | White Solid | Uses | 4β-Hydroxy Cholesterol-d7 is a labelled metabolite of Cholesterol. It is formed from Cholesterol by the drug-metabolizing enzyme cytochrome P 450 3A4. A potential ligand for the nuclear receptor LXR and also a new endogenous CYP3A marker. | Uses | 4β-hydroxycholesterol-d7 has been used:
- as an internal standard to spike plasma samples ultra-high-pressure liquid,chromatography–tandem mass spectrometry (UHPLC-MS/MS) analysis
- to spike serum samples for mass spectrometry measurements
- as an internal standard for the quantification of human colon biopsies samples using HPLC-MS
| General Description | 4β-hydroxycholesterol (4β-HC) is a catabolic product of cholesterol metabolism mediated by the enzyme cytochrome P450 family 3 subfamily A member 4 (CYP3A4). 4β-hydroxycholesterol-d7 is the deuterated form of 4β-hydroxycholesterol. | Biochem/physiol Actions | 4β-hydroxycholesterol (4β-HC) may function as a liver X receptor ligand. The levels of 4β-HC are elevated in dextran sulfate induced colitis along with other oxysterols and it may promote colon inflammation. |
| 4-Hydroxy Cholesterol-d7 Preparation Products And Raw materials |
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