| Company Name: |
BOC Sciences
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1-631-485-4226; 16314854226 |
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info@bocsci.com |
| Products Intro: |
Product Name:TC-A 2317 hydrochloride
CAS:1245907-03-2
Purity:98% by HPLC Remarks:TC-A 2317 hydrochloride is a selective and potent Aurora kinase A (ARK-1) inhibitor (Ki = 1.2 nM and 101 nM for inhibition of Aurora kinase A and Aurora kinase B, respectively) with selectivity over 6
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| Company Name: |
MedBioPharmaceutical Technology Inc
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021-69568360 18916172912 |
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order@med-bio.cn |
| Products Intro: |
Product Name:TC-A 2317 hydrochloride
CAS:1245907-03-2
Purity:98% Package:50mg; 10mg Remarks:Medbio
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| | TC-A 2317 hydrochloride Basic information |
| Product Name: | TC-A 2317 hydrochloride | | Synonyms: | TC-A 2317 hydrochloride;TC-A-2317 HCl;2-[(5-Hydroxy-1,5-dimethylhexyl)amino]-4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile hydrochloride;Reaxys ID: 20640556;permeability,oral,Inhibitor,selective,antitumor,inhibit,HCT-116,TC A 2317 hydrochloride,TCA 2317 hydrochloride,Aurora Kinase,proliferation,TC-A 2317 | | CAS: | 1245907-03-2 | | MF: | C19H29ClN6O | | MW: | 392.93 | | EINECS: | | | Product Categories: | | | Mol File: | 1245907-03-2.mol |  |
| | TC-A 2317 hydrochloride Chemical Properties |
| storage temp. | Store at 4°C | | solubility | Soluble to 100 mM in DMSO and to 50 mM in ethanol | | form | Powder |
| | TC-A 2317 hydrochloride Usage And Synthesis |
| Biochem/physiol Actions | TC-A2317 (TC-A 2317) is an orally active, potent and selective aurora A kinase inhibitor (Ki = 1.2 nM; Aurora B Ki = 101 nM; IC50 >1 μM toward 60 other kinases). TC-A2317 inhibits the proliferation of human colorectal carcinoma HCT116 cells in cultures (IC50 = 115 nM) and suppresses HCT116 xenograft-derived tumor growth in mice in vivo (by 59% on day 14; 30 mg/kg/day p.o.) with good pharmacokinectic properties, oral bioavailability (Tmax = 1.2 h, T1/2 = 3.3 h, Cmax = 4930 nM, C60 min = 52 nM in rat serum post 30 mg/kg p.o.), and no adverse effects to the animals. TC-A231 is a racemate with its (S)-enantiomer being more active than the (R)-enantiomer (respective Ki = 0.59 vs. 66 nM). | | storage | Store at +4°C |
| | TC-A 2317 hydrochloride Preparation Products And Raw materials |
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