| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
|
| Tel: |
400-9205774 |
| Email: |
sales@glpbio.cn |
| Products Intro: |
Product Name:CAY10581
CAS:1018340-07-2
Purity:>98% Package:1mg;10mg;50mg;100mg;
|
| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:CAY10581
CAS:1018340-07-2
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing1@energy-chemical.com |
| Products Intro: |
Product Name:CAY10581
CAS:1018340-07-2
Purity:NULL Package:1mg;2.5mg Remarks:NULL
|
| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:CAY10581 Exclusive
CAS:1018340-07-2
Purity:97% Package:1mg;5mg;10mg
|
|
| | CAY10581 Basic information |
| Product Name: | CAY10581 | | Synonyms: | CAY10581;CAY10581 Exclusive;2H-Naphtho[2,3-b]pyran-5,10-dione, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-[(phenylmethyl)amino]-, (3R,4R)-rel- | | CAS: | 1018340-07-2 | | MF: | C22H21NO4 | | MW: | 363.41 | | EINECS: | | | Product Categories: | | | Mol File: | 1018340-07-2.mol |  |
| | CAY10581 Chemical Properties |
| Boiling point | 548.8±50.0 °C(Predicted) | | density | 1.32±0.1 g/cm3(Predicted) | | solubility | DMF: 10 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 3 mg/ml | | form | A crystalline solid | | pka | 12.53±0.60(Predicted) |
| | CAY10581 Usage And Synthesis |
| Description | The enzyme indoleamine 2,3-dioxygenase (IDO) has been implicated in mediating pathological immunosuppression associated with certain diseases, including cancer. Several naphthoquinones inhibit IDO in vitro and in cells, but at low (μM) potency. Importantly, naphthoquinones reduce tumor growth in wild type mice but not in IDO-deficient mice. CAY10581 is a naphthoquinone derivative that potently inhibits IDO (IC50 = 55 nM). It is a more potent inhibitor of IDO than annulin B or 1-methyl-d-tryptophan (1MT). CAY10581 acts as a reversible uncompetitive inhibitor of IDO and demonstrates minimal impact on cell viability at 100 μM after 24 hours. | | Uses | CAY10581 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor. |
| | CAY10581 Preparation Products And Raw materials |
|