| Company Name: |
MedBioPharmaceutical Technology Inc
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| Tel: |
021-69568360 18916172912 |
| Email: |
order@med-bio.cn |
| Products Intro: |
Product Name:Δ17-U-46619
CAS:946602-01-3
Purity:98% Package:1mg (solution); 50ug (solution); 100ug (solution); 500ug (solution) Remarks:Medbio
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| Company Name: |
Cayman Chemical Company
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| Tel: |
(800) 364-9897 |
| Email: |
cayman@caymanchem.com |
| Products Intro: |
Product Name:Δ17-U-46619
CAS:946602-01-3
Package:>98% Remarks:16460
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| Company Name: |
Absin Bioscience Inc.
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| Tel: |
021-38015121 |
| Email: |
chenjw@absin.cn |
| Products Intro: |
Product Name:δ17-U-46619
CAS:946602-01-3
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| | Δ17-U-46619 Basic information |
| Product Name: | Δ17-U-46619 | | Synonyms: | Δ17-U-46619;XXHSKVZXPIQTFH-JCJONVDGSA-N;Δ17-U-46619;5-Heptenoic acid, 7-[(1R,4S,5S,6R)-6-[(1E,,3S,5Z)-3-hydroxy-1,5-octadien-1-yl]-2-oxabicyclo[2.2.1]hept-5-yl]-, (5Z)- | | CAS: | 946602-01-3 | | MF: | C21H32O4 | | MW: | 348.48 | | EINECS: | | | Product Categories: | | | Mol File: | 946602-01-3.mol |  |
| | Δ17-U-46619 Chemical Properties |
| Boiling point | 520.5±40.0 °C(Predicted) | | density | 1.107±0.06 g/cm3(Predicted) | | solubility | DMF: >100 mg/ml; DMSO: >100 mg/ml; Ethanol: >100 mg/ml; PBS pH 7.2: >2 mg/ml | | pka | 4.76±0.10(Predicted) |
| | Δ17-U-46619 Usage And Synthesis |
| Description | U-46619 is the consensus stable analog of prostaglandin H2/thromboxane A2 (PGH2/TXA2) and has been used as a TXA2 agonist in pharmacologic studies for several decades.1 There have been several hypotheses put forward by scientists studying ω-3 fatty acids stipulating that the agonist activity of TXA3 was substantially different than that of TXA2.2 However, no stable analogs of TXA3 were available to test these theories. Δ17-U-46619 is the first direct, stable analog of TXA3 ever synthesized. There are no published reports on its activity to date. | | References | 1. Bundy, G.L. The synthesis of prostaglandin endoperoxide analogs Tetrahedron Lett. 24,1957-1960(1975).
2. Parent, C.A., Lagarde, M., Venton, D.L., et al. Selective modulation of the human platelet thromboxane A2/prostaglandin H2 receptor by eicosapentaenoic and docosahexaenoic acids in intact platelets and solubilized platelet membranes J. Biol. Chem. 267,6541-6547(1992). |
| | Δ17-U-46619 Preparation Products And Raw materials |
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