BMS-5
| 中文名称 | BMS-5 |
|---|---|
| 中文同义词 | BMS-5游离态;化合物BMS5;N-(5-(1-(2,6-二氯苯基)-3-(二氟甲基)-1H-吡唑-5-基)噻唑-2-基)异丁酰胺;LIMKI 3,LIM激酶抑制剂 |
| 英文名称 | N-(5-(1-(2,6-dichlorophenyl)-3-(difluoroMethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyraMide |
| 英文同义词 | N-(5-(1-(2,6-dichlorophenyl)-3-(difluoroMethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyraMide;LIMKI-3;Mitoquinone mesylateN-{5-[1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]- 1,3-thiazol-2-yl}-2-methylpropanamide;BMS-5， LIMKI-3;CS-2190;BMS-5 ≥95%;BMS 5;BMS5;N-{5-[1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]- 1,3-thiazol-2-yl}-2-methylpropanamide |
| CAS号 | 1338247-35-0 |
| 分子式 | C17H14Cl2F2N4OS |
| 分子量 | 431.29 |
| EINECS号 | |
| 相关类别 | 抑制剂 |
| Mol文件 | 1338247-35-0.mol |
| 结构式 |  |
BMS-5 性质
| 密度 | 1.54±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | Sealed in dry,Store in freezer, under -20°C |
| 溶解度 | DMSO:PBS (pH 7.2) (1:5):0.2(最大浓度 mg/mL);0.46(最大浓度 mM) 乙醇:3.0(最大浓度 mg/mL);6.96(最大浓度 mM) 。 mM） |
| 酸度系数(pKa) | 9.51±0.50(Predicted) |
| 形态 | 白色粉末 |
| 颜色 | 白色至米白色 |
| Target | Value |
|
LIMK1
(Cell-free assay) | 7 nM |
|
LIMK2
(Cell-free assay) | 8 nM |
BMS-5 (LIMKi 3) inhibits cofilin-Ser3 phosphorylation in a dose-dependent manner in Nf2 ΔEx2 mouse Schwann cells (MSCs) with an IC 50 of ~2 µM. BMS-5 (LIMKi 3) reduces Nf2 ΔEx2 MSC viability in a dose-dependent manner with an IC 50 of 3.9 µM, but does not significantly reduce the viability of control Nf2 flox2/flox2 MSCs at equivalent BMS-5 concentrations. At 10 µM BMS-5, Nf2 ΔEx2 MSC viability is 40% compared to 83% for controls.
BMS-5 (LIMKi 3) (20 or 200 μM/side) is bilaterally infused into the hippocampus of rats immediately after contextual fear conditioning training. Rats are tested for memory consolidation 48 h after fear conditioning. Post hoc analysis shows that the group treated with 200 μM BMS-5 express lower freezing levels compared to the 20 μM and vehicle groups (P<0.01).
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | S0185 | BMS-5 BMS-5 | 1338247-35-0 | 5mg | 857.46元 |
| 2024/04/30 | S0185 | BMS-5 BMS-5 | 1338247-35-0 | 25mg | 1775.47元 |