| Company Name: |
Haoyuan Chemexpress Co., Ltd.
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| Tel: |
021-58950125 |
| Email: |
info@chemexpress.com |
| Products Intro: |
Product Name:IRAK inhibitor 4
CAS:1012104-68-5
Purity:>98% Package:4466RMB/2mg
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| | 1-(4-Hydroxycyclohexyl)-2-[[5-(2-trifluoromethoxyphenyl)-1H-indazol-3-yl]amino]-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide Basic information |
| | 1-(4-Hydroxycyclohexyl)-2-[[5-(2-trifluoromethoxyphenyl)-1H-indazol-3-yl]amino]-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide Chemical Properties |
| density | 1.41 | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Powder | | pka | 13.54±0.40(Predicted) | | color | Off-white to light brown |
| | 1-(4-Hydroxycyclohexyl)-2-[[5-(2-trifluoromethoxyphenyl)-1H-indazol-3-yl]amino]-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide Usage And Synthesis |
| Biological Activity | irak inhibitor 4 is an inhibitor of interleukin- 1 receptor-associated kinase [1].irak-4 belongs to interleukin-1 receptor-associated kinase, which are key components in the signal transduction pathways. irak-4 is an essential signal transducer downstream of interleukin-1 receptor (il-1r), interleukin-18 receptor (il-18r) and toll-like receptors (tlrs). inhibition of irak-4 can modulate its function, thus toning down inflammatory responses. irak inhibitor 4 is an indazole inhibitor. as inhibitors of irak-4, imidazo[1,2-b]pyridazines and indazoles are used for treatment of some inflammatory, cell proliferative and immune-related disorders [1]. | | target | IRAK | | references | [1] zhulun wang, holger wesche, tracey stevens, nigel walker and wen-chen yeh. irak-4 inhibitors for inflammation. current topics in medicinal chemistry. 2009, 9: 724-737. |
| | 1-(4-Hydroxycyclohexyl)-2-[[5-(2-trifluoromethoxyphenyl)-1H-indazol-3-yl]amino]-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide Preparation Products And Raw materials |
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