- af-353
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- $100.00 / 1KG
-
2022-02-25
- CAS:865305-30-2
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 100KG
- af-353
-
- $100.00 / 1Kg/Bag
-
2022-02-25
- CAS:865305-30-2
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10kg
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| 2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- Basic information |
Product Name: | 2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- | Synonyms: | 2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-;AF 353;Ro 4;5-{[5-iodo-2-(1-Methylethyl)-4-(Methyloxy)phenyl]oxy}-2,4-pyriMidinediaMine;AF-353 (Ro-4);5-[5-Iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine;5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine hydrochloride Ro 4 hydrochloride;CS-2469 | CAS: | 865305-30-2 | MF: | C14H17IN4O2 | MW: | 400.21 | EINECS: | | Product Categories: | Inhibitors | Mol File: | 865305-30-2.mol | ![2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- Structure](CAS/GIF/865305-30-2.gif) |
| 2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- Chemical Properties |
Boiling point | 510.2±60.0 °C(Predicted) | density | 1.619±0.06 g/cm3(Predicted) | storage temp. | Store at -20°C | solubility | DMSO : ≥ 32 mg/mL (79.96 mM) | form | Solid | pka | 6.89±0.10(Predicted) | color | Light brown to brown |
| 2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- Usage And Synthesis |
Description | AF-353 is a noncompetitive dual antagonist of the purinoreceptors P2X3 and P2X2/3 (IC50s = 10 and 79.4 nM, respectively). It is selective for P2X3 and P2X2/3 over P2X1, P2X2, P2X4, P2X5, and P2X7 (IC50 = >10 μM for all). It inhibits calcium flux in CHO-K1 cells expressing the rat P2X3 receptor and in 1321N1 cells expressing the human P2X3 and P2X2/3 receptors (IC50s = 8.91, 8.71, and 38.9 nM, respectively). AF-353 decreases the electrical signals in the detrusor, but not striated, muscle of the bladder in female rats. |
| 2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- Preparation Products And Raw materials |
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