- Vidofludimus
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- $0.00 / 1Kg
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2024-04-07
- CAS:717824-30-1
- Min. Order: 1Kg
- Purity: 99.9%
- Supply Ability: 200tons
- VidofludiMus
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- $9.80 / 1.79999995231628KG
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2020-01-13
- CAS:717824-30-1
- Min. Order: 1g
- Purity: ≥99%
- Supply Ability: 100kg
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| | VidofludiMus Basic information |
| Product Name: | VidofludiMus | | Synonyms: | VidofludiMus;SC12267);VidofludiMus(4SC-101;VIDOFLUDIMUS(4SC-101; SC12267);2-[[(3-Fluoro-3'-methoxy[1,1'-biphenyl]-4-yl)amino]carbonyl]-1-cyclopentene-1-carboxylic acid;2-[(3-Fluoro-3'-methoxy-4-biphenylyl)carbamoyl]-1-cyclopentene-1-carboxylic acid;2-[(3-fluoro-3'-methoxybiphenyl-4-yl)carbamoyl]cyclopent-1-ene-1-carboxylic acid Vidofludimus(4SC-101;CS-1196 | | CAS: | 717824-30-1 | | MF: | C20H18FNO4 | | MW: | 355.36 | | EINECS: | | | Product Categories: | API;Inhibitors | | Mol File: | 717824-30-1.mol |  |
| | VidofludiMus Chemical Properties |
| Boiling point | 567.5±50.0 °C(Predicted) | | density | 1.354±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | insoluble in H2O; insoluble in EtOH; ≥103 mg/mL in DMSO | | form | solid | | pka | 4?+-.0.20(Predicted) | | color | Light yellow to gray |
| | VidofludiMus Usage And Synthesis |
| Uses | Vidofludimus is an immunosuppressive drug that inhibits dihydroorotate dehydrogenase (DHODH) and the expression of proinflammatory cytokines including interleukin-17 (IL17A and IL17F) and interferon-gamma. | | Biological Activity | vidofludimus (4sc-101, sc12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (dhodh) with an ic50 value of 134nmol/l for human dhodh [1].vidofludimus (4sc-101, sc12267) has been reported to dose-dependently inhibit dhodh in an in vitro enzyme assay with ic50 values of 0.134μmol/l, 1.29μmol/l, 10.6μmol/l and 12.9μmol/l in human dhodh, rat dhodh, mouse dhodh and human pbmc, respectively [1]. in addition, vidofludimus has shown the inhibition of proliferation in phytohemagglutinin-induced lymphocytes with an ic50 value of ~13μmol/l. moreover, vidofludimus has been revealed to concentration-dependently inhibit phytohemagglutinin-stimulated interukin-17 secretion from human peripgeral blppd mononuclear cell lines (pbmcs) with an ic50 value of 6 μmol/l [2]. | | references | [1] kulkarni op1, sayyed sg, kantner c, ryu m, schnurr m, sárdy m, leban j, jankowsky r, ammendola a, doblhofer r, anders hj. 4sc-101, a novel small molecule dihydroorotate dehydrogenase inhibitor, suppresses systemic lupus erythematosus in mrl-(fas) lpr mice. am j pathol. 2010 jun;176(6):2840-7.
[2] fitzpatrick lr1, deml l, hofmann c, small js, groeppel m, hamm s, lemstra s, leban j, ammendola a. 4sc-101, a novel immunosuppressive drug, inhibits il-17 and attenuates colitis in two murine models of inflammatory bowel disease. inflamm bowel dis. 2010 oct;16(10):1763-77. |
| | VidofludiMus Preparation Products And Raw materials |
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