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NCE Biomedical Co.,Ltd.
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Product Name:LY2140023 hydrochloride CAS:635318-26-2 Purity:99% HPLC Package:50Mg,100Mg,500Mg,1g,5g,10g,50g,100g,500g,1kg Remarks:XYA0455
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LETOPHARM LIMITED
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Product Name:LY2140023 hydrochloride CAS:635318-26-2
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SPIRO PHARMA
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Product Name:LY2140023 hydrochloride CAS:635318-26-2 Purity:95% -98%HPLC Package:1GR;10GR;50GR;100GR;250GR;500GR;1KG;5KG;10KG;100KG
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ShangHai ChuanQian Chemcial Technique Centre
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15869524721 |
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Product Name:LY2140023 Hydrochloride CAS:635318-26-2 Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G,10G
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| LY2140023 hydrochloride Basic information |
| LY2140023 hydrochloride Chemical Properties |
storage temp. | 4°C, stored under nitrogen | form | Solid | color | Off-white to light yellow |
| LY2140023 hydrochloride Usage And Synthesis |
Biological Activity | Pomaglumetad methionil hydrochloride (LY2140023 hydrochloride) is an orally active, methionine prodrug of the selective mGlu2/3 receptor agonist LY404039. Pomaglumetad methionil hydrochloride has the potential for schizophrenia research[1][2].
Pomaglumetad methionil (LY2140023) is a high-affinity peptide transporter 1 (PEPT1) substrate with a Km value of ~30 μM[2].LY2140023 is active against [14C]Gly-Sar with an IC50 value of 0.018 mM[2].
Pomaglumetad methionil (LY2140023; orally; 3-300 mg/kg; once daily for 7 days) dose-dependent increases the levels of the dopamine metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) [1]. | References | [1]. Lowe S, et al. Effects of a novel mGlu?/? receptor agonist prodrug, LY2140023 monohydrate, on central monoamine turnover as determined in human and rat cerebrospinal fluid. Psychopharmacology (Berl). 2012 Feb;219(4):959-70. [2]. Y Anne Pak, et al. In Vitro and Clinical Evaluations of the Drug-Drug Interaction Potential of a Metabotropic Glutamate 2/3 Receptor Agonist Prodrug with Intestinal Peptide Transporter 1. Drug Metab Dispos. 2017 Feb;45(2):137-144. |
| LY2140023 hydrochloride Preparation Products And Raw materials |
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