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MedChemexpress LLC
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Product Name:Anamorelin Fumarate
CAS:339539-92-3
Purity:>98% Package:1000RMB/5mg
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| Company Name: |
AdooQ BioScience, LLC
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+1 (866) 930-6790 |
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info@adooq.com |
| Products Intro: |
Product Name:Anamorelin Fumarate
CAS:339539-92-3
Purity:98% Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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| | ONO 7643 FuMarate Basic information |
| Product Name: | ONO 7643 FuMarate | | Synonyms: | AnaMorelin (FuMarate);ONO 7643 FuMarate;ONO7643 FuMarate;ONO-7643 FuMarate;RC 1291 FuMarate;RC1291 FuMarate;RC-1291 FuMarate;Anamorelin (RC-1291) Fumarate | | CAS: | 339539-92-3 | | MF: | C35H46N6O7 | | MW: | 662.79 | | EINECS: | | | Product Categories: | | | Mol File: | 339539-92-3.mol |  |
| | ONO 7643 FuMarate Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | | form | Powder |
| | ONO 7643 FuMarate Usage And Synthesis |
| Description | Anamorelin Fumarate is a novel ghrelin receptor agonist with EC50 value of 0.74 nM in the FLIPR assay. | | in vitro | In Vitro:In the FLIPR assay, Anamorelin (ANAM) shows significant agonist activity on the ghrelin receptor, with EC50 value of 0.74 nM. No significant antagonist activity is observed with Anamorelin at concentrations of up to 1,000 nM. In the binding experiments, Anamorelin binds to the ghrelin receptor with a binding affinity constant (Ki) of 0.70 nM. In the competition assay with radiolabeled ibutamoren (35S-MK-677; another ghrelin receptor agonist) Anamorelin (ANAM) is also found to bind with high affinity to the ghrelin receptor (IC50=0.69 nM). In rat pituitary cells incubated with Anamorelin, there is a dose-dependent stimulatory effect on GH release and the potency (EC50) is 1.5 nM. Anamorelin is screened for activity against a set of over 100 receptors, ion channels, transporters, and enzymes. Anamorelin demonstrates binding to the tachykinin neurokinin 2 (NK2) site (IC50=0.021 μM); however, a subsequent NK2 functional assay demonstrates no functional activity[1]. | | in vivo | In Vivo:In rats, Anamorelin (ANAM) at an oral dose of 3, 10, or 30 mg/kg once daily significantly increases both food intake and body weight from Day 2 to Day 7 of treatment compared with the vehicle control. The cumulative change in food intake and weight gain increases dose-dependently, and these changes are significant at all dose levels (P<0.05) compared to the control. Administration of Anamorelin at a single oral dose of 3, 10, or 30 mg/kg induces a dose-dependent increase in plasma GH levels and GH AUC0-6h in rats[1]. | | References | References:[1]. Pietra C, et al. Anamorelin HCl (ONO-7643), a novel ghrelin receptor agonist, for the treatment of cancer anorexia-cachexiasyndrome: preclinical profile. J Cachexia Sarcopenia Muscle. 2014 Dec;5(4):329-37. |
| | ONO 7643 FuMarate Preparation Products And Raw materials |
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