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LY 2801653 dihydrochloride

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Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:Merestinib dihydrochloride；LY2801653 dihydrochloride
CAS:1206801-37-7
Purity:98.00% Package:10 mg；100 mg；2 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Career Henan Chemica Co
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Products Intro: Product Name:LY 2801653 dihydrochloride
CAS:1206801-37-7
Purity:85.0-99.8% Package:1KG;1USD
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:Merestinib dihydrochloride
CAS:1206801-37-7
Purity:98% Package:5mg Remarks:V33593
Company Name: TargetMol Chemicals Inc.
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Email: support@targetmol.com
Products Intro: Product Name:Merestinib dihydrochloride
CAS:1206801-37-7
Package:5mg;130USD|2mg;62USD
Company Name: Wuhan Topule Biopharmaceutical Co., Ltd
Tel: +8618327326525
Email: masar@topule.com
Products Intro: Product Name:Merestinib dihydrochloride
CAS:1206801-37-7
Purity:95% Package:100mg;1g;500g Remarks:Topule Company operates with integrity and has its own laboratory, which supports packaging and customization. Payment will be made after the product has passed third-party testing

LY 2801653 dihydrochloride manufacturers
LY 2801653 dihydrochloride Basic information
Product Name:LY 2801653 dihydrochloride
Synonyms:LY 2801653 dihydrochloride;LY2801653 (dihydrochloride);LY-2801653 dihydrochloride;N-[3-Fluoro-4-[[1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yl]oxy]phenyl]-1-(4-fluorophenyl)-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarboxamide hydrochloride (1:2);CS-1046;LY-2801653 DIHYDROCHLORIDE; LY 2801653 DIHYDROCHLORIDE;LY2801653;Merestinib(LY2801653 dihydrochloride);LY2801653 2HCl
CAS:1206801-37-7
MF:C30H23ClF2N6O3
MW:589
EINECS:
Product Categories:
Mol File:1206801-37-7.mol
LY 2801653 dihydrochloride Structure
LY 2801653 dihydrochloride Chemical Properties
storage temp. Store at -20°C, sealed storage, away from moisture
solubility DMSO: ≥ 100 mg/mL (159.88 mM)
form Powder
color White to light yellow
Safety Information
MSDS Information
LY 2801653 dihydrochloride Usage And Synthesis
UsesN-[3-Fluoro-4-[[1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yl]oxyphenyl]-1-(4-fluorophenyl)-6-methyl-2-oxopyridine-3-carboxamide dihydrochloride is used as a reactant/reagent in synthetic preparation of amidophenoxyindazoles as inhibitors of c-Met.
in vivo

Merestinib (LY2801653) demonstrates anti-tumor effects in MET amplified (MKN45), MET autocrine (U-87MG, and KP4) and MET over-expressed (H441) xenograft models; and in vivo vessel normalization effects. Merestinib (LY2801653) is a type-II ATP competitive, slow-off inhibitor of MET tyrosine kinase with a pharmacodynamic residence time (Koff) of 0.00132 min-1 and t1/2 of 525 min. Merestinib (LY2801653) treatment inhibits MET phosphorylation with a composite TED50 (50 % target inhibition dose) of 1.2 mg/kg and a composite TED90 (90 % target inhibition dose) of 7.4 mg/kg[1]. Merestinib (LY2801653) (20 mg/kg) reduces TFK-1 tumor growth significantly relative to vehicle control. Merestinib (LY2801653) inhibits the growth of intra- and extrahepatic CCC xenograft tumors[2].

LY 2801653 dihydrochloride Preparation Products And Raw materials
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