- Kobe2602
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- $82.00 / 100mg
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2024-10-30
- CAS:454453-49-7
- Min. Order:
- Purity: 99.39%
- Supply Ability: 10g
- KOBE-2602
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- $1.00 / 1ASSAYS
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2019-09-05
- CAS:454453-49-7
- Min. Order: 1ASSAYS
- Purity: 96%
- Supply Ability: 10kg
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| kobe-2602 Basic information |
| kobe-2602 Chemical Properties |
Boiling point | 450.8±55.0 °C(Predicted) | density | 1.691±0.06 g/cm3(Predicted) | storage temp. | Store at -20°C | solubility | insoluble in H2O; ≥17 mg/mL in DMSO; ≥17.53 mg/mL in EtOH with ultrasonic | pka | 9.35±0.70(Predicted) | form | solid | color | Light yellow to brown |
| kobe-2602 Usage And Synthesis |
Uses | 2-[2,6-Dinitro-4-(trifluoromethyl)phenyl]-N-(4-fluorophenyl)hydrazinecarbothioamide is used in the preparation of pyrazolidine or pyrazole compounds which exhibit mild antimicrobial effects against various strains of bacteria. | Uses | Kobe 2602 is used in the preparation of pyrazolidine or pyrazole compounds which exhibit mild antimicrobial effects against various strains of bacteria. | Biological Activity | kobe2602 is a small-molecule inhibitor of ras with ki value of 149 μm [1].kobe2602 is a compound screened out by a computer-assisted search of about 160,000 compounds. it dose-dependently inhibited the binding of h-rasg12v to c-raf-1 in nih 3t3 cells with a rough ic50 value of 10 μm. 20 μm of kobe2602 effectively suppressed the phosphorylation of down-stream kinases of raf, including mek and erk. besides that, in nih 3t3 cells transfected with h-rasg12v, kobe2602 inhibited the colony formation with ic50 value of 1.4 μm. kobe2602 also showed effect on other cancer cells carrying activated ras oncogenes, such as panc-1(k-rasg12v), ht1080 (n-rasq61l) and hct116 (h-rasg13d). moreover, in mice bearing sw480 xenografts, administration of kobe2602 resulted in 40-50% inhibition of the tumor growth at dose of 80 mg/kg [1]. | references | [1] shima f, yoshikawa y, ye m, et al. in silico discovery of small-molecule ras inhibitors that display antitumor activity by blocking the ras–effector interaction. proceedings of the national academy of sciences, 2013, 110(20): 8182-8187. |
| kobe-2602 Preparation Products And Raw materials |
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