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kobe-2602

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Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:kobe2602
CAS:454453-49-7
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695
Email: sales@coreychem.com
Products Intro: Product Name: KOBE-2602
CAS:454453-49-7
Purity:96% Package:1ASSAYS;1USD
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:Kobe2602
CAS:454453-49-7
Purity:99.39% Package:100mg;82USD|50mg;44USD|25mg;29USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:Kobe-2602
CAS:454453-49-7
Purity:98% Package:10mg Remarks:V5211
Company Name: ShenZhen Trendseen Biological Technology Co.,Ltd.
Tel: 13417589054
Email: trendseenbio@gmail.com
Products Intro: Product Name:kobe-2602
CAS:454453-49-7
Purity:99% Package:1kg；25kg

kobe-2602 manufacturers

  • Kobe2602
  • Kobe2602 pictures
  • $82.00 / 100mg
  • 2024-10-30
  • CAS:454453-49-7
  • Min. Order:
  • Purity: 99.39%
  • Supply Ability: 10g
  • KOBE-2602
  • KOBE-2602 pictures
  • $1.00 / 1ASSAYS
  • 2019-09-05
  • CAS:454453-49-7
  • Min. Order: 1ASSAYS
  • Purity: 96%
  • Supply Ability: 10kg
kobe-2602 Basic information
Product Name:kobe-2602
Synonyms:kobe 2602;kobe2602;kobe-2602;2-[2,6-Dinitro-4-(trifluoroMethyl)phenyl]-N-(4-fluorophenyl)hydrazinecarbothioaMide;kobe-2602 2-[2,6-Dinitro-4-(trifluoromethyl)phenyl]-N-(4-fluorophenyl)hydrazinecarbothioamide;Kobe 2602, >=98%;kobe2602, >96%;CS-1280
CAS:454453-49-7
MF:C14H9F4N5O4S
MW:419.31
EINECS:
Product Categories:Inhibitors;Aromatics, Miscellaneous Reagents, Pharmaceuticals, Intermediates & Fine Chemicals
Mol File:454453-49-7.mol
kobe-2602 Structure
kobe-2602 Chemical Properties
Boiling point 450.8±55.0 °C(Predicted)
density 1.691±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility insoluble in H2O; ≥17 mg/mL in DMSO; ≥17.53 mg/mL in EtOH with ultrasonic
pka9.35±0.70(Predicted)
form solid
color Light yellow to brown
Safety Information
MSDS Information
kobe-2602 Usage And Synthesis
Uses2-[2,6-Dinitro-4-(trifluoromethyl)phenyl]-N-(4-fluorophenyl)hydrazinecarbothioamide is used in the preparation of pyrazolidine or pyrazole compounds which exhibit mild antimicrobial effects against various strains of bacteria.
UsesKobe 2602 is used in the preparation of pyrazolidine or pyrazole compounds which exhibit mild antimicrobial effects against various strains of bacteria.
Biological Activitykobe2602 is a small-molecule inhibitor of ras with ki value of 149 μm [1].kobe2602 is a compound screened out by a computer-assisted search of about 160,000 compounds. it dose-dependently inhibited the binding of h-rasg12v to c-raf-1 in nih 3t3 cells with a rough ic50 value of 10 μm. 20 μm of kobe2602 effectively suppressed the phosphorylation of down-stream kinases of raf, including mek and erk. besides that, in nih 3t3 cells transfected with h-rasg12v, kobe2602 inhibited the colony formation with ic50 value of 1.4 μm. kobe2602 also showed effect on other cancer cells carrying activated ras oncogenes, such as panc-1(k-rasg12v), ht1080 (n-rasq61l) and hct116 (h-rasg13d). moreover, in mice bearing sw480 xenografts, administration of kobe2602 resulted in 40-50% inhibition of the tumor growth at dose of 80 mg/kg [1].
references[1] shima f, yoshikawa y, ye m, et al. in silico discovery of small-molecule ras inhibitors that display antitumor activity by blocking the ras–effector interaction. proceedings of the national academy of sciences, 2013, 110(20): 8182-8187.
kobe-2602 Preparation Products And Raw materials
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