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| | S1RA (hydrochloride) Basic information |
| Product Name: | S1RA (hydrochloride) | | Synonyms: | S1RA (hydrochloride);4-[2-[[5-Methyl-1-(2-naphthalenyl)-1H-pyrazol-3-yl]oxy]ethyl]morpholine hydrochloride (1:1);4-(2-(5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy)ethyl)morpholine hydrochloride;S1RA. HCL;E 52862 hydrochloride;E52862 hydrochloride;E-52862 hydrochloride;E-52862 HYDROCHLORIDE;E52862 HYDROCHLORIDE;E 52862 HYDROCHLORIDE | | CAS: | 1265917-14-3 | | MF: | C20H24ClN3O2 | | MW: | 373.88 | | EINECS: | 931-042-6 | | Product Categories: | | | Mol File: | 1265917-14-3.mol |  |
| | S1RA (hydrochloride) Chemical Properties |
| storage temp. | -20°C (des.) | | solubility | Soluble in DMSO (up to at least 25 mg/ml) | | form | solid | | color | Off-white | | Stability: | Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| | S1RA (hydrochloride) Usage And Synthesis |
| Description | S1RA (E-52862, 1265917-14-3) is a potent and selective σ1 antagonist with weak binding at σ2?(IC50?σ1 = 17nM, σ2 = 9300nM).1,2?S1RA abolished mechanical and thermal hyperalgesia in mice with carrageenan-induced acute inflammation by enhancing the action of endogenous opioid peptides of immune origin in a σ1 dependent manner.3?S1RA potentiated μ-opioid antinociception in mice in a σ-dependent manner.4?S1RA displayed neuroprotective effects in a mouse model of ischemic stroke.5 | | References | References/Citations |
| | S1RA (hydrochloride) Preparation Products And Raw materials |
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