| Company Name: |
J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788 |
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jkinfo@jkchemical.com |
| Products Intro: |
Product Name:3,3-DiMethyl-1-[difluoro(phenylsulfonyl)Methyl]-1,2-benziodoxole
CAS:1052174-67-0
Purity:98% Package:1G
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| Company Name: |
Daicel Chiral Technologies (China)CO.,LTD
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| Tel: |
021-50460086-9 15921403865 |
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han_yajun@dctc.daicel.com |
| Products Intro: |
Product Name:1-[Difluoro(phenylsulfonyl)methyl]-1,3-dihydro-3,3-dimethyl-1,2-benziodoxole
CAS:1052174-67-0
Purity:95%/98% Package:1G;100G; 1KG Remarks:201194
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| | 3,3-DiMethyl-1-[difluoro(phenylsulfonyl)Methyl]-1,2-benziodoxole Basic information |
| Product Name: | 3,3-DiMethyl-1-[difluoro(phenylsulfonyl)Methyl]-1,2-benziodoxole | | Synonyms: | 3,3-DiMethyl-1-[difluoro(phenylsulfonyl)Methyl]-1,2-benziodoxole;1-(difluoro(phenylsulfonyl)methyl)-3,3-dimethyl-1,3-dihydro-1l3-benzo[d][1,2]iodaoxole;1-[Difluoro(phenylsulfonyl)methyl]-1,3-dihydro-3,3-dimethyl-1,2-benziodoxole;1,2-Benziodoxole, 1-[difluoro(phenylsulfonyl)methyl]-1,3-dihydro-3,3-dimethyl-;1-(Difluoro(phenylsulfonyl)methyl)-3,3-dimethyl-1,3-dihydro-1lambda3-benzo[d][1,2]iodaoxole | | CAS: | 1052174-67-0 | | MF: | C16H15F2IO3S | | MW: | 452.25 | | EINECS: | | | Product Categories: | | | Mol File: | 1052174-67-0.mol | ![3,3-DiMethyl-1-[difluoro(phenylsulfonyl)Methyl]-1,2-benziodoxole Structure](CAS/20150408/GIF/1052174-67-0.gif) |
| | 3,3-DiMethyl-1-[difluoro(phenylsulfonyl)Methyl]-1,2-benziodoxole Chemical Properties |
| | 3,3-DiMethyl-1-[difluoro(phenylsulfonyl)Methyl]-1,2-benziodoxole Usage And Synthesis |
| Description | 3,3-Dimethyl-1-[difluoro(phenylsul
fonyl)methyl]-1,2-benziodoxole is a novel electrophilic difluoromethylation reagent prepared from TMSCF2SO2Ph, which can
efficiently transfer the PhSO2CF2 moiety to nucleophiles such as thiols under mild reaction
conditions. Copper(II)-catalyzed decarboxylative difluoro(phenylsulfonyl)methylation of α,β- or
β,γ-unsaturated carboxylic acids with this reagent can afford vinylic and allylic
difluoromethylation products. | | Reactions | (1) Difluoromethylation of thiols.
![3,3-DiMethyl-1-[difluoro(phenylsulfonyl)Methyl]-1,2-benziodoxole](/NewsImg/2024-01-23/6384160274293716773902182.png "3,3-DiMethyl-1-[difluoro(phenylsulfonyl)Methyl]-1,2-benziodoxole")
(2) Difluoromethylation of β,γ-unsaturated carboxylic acids.
![3,3-DiMethyl-1-[difluoro(phenylsulfonyl)Methyl]-1,2-benziodoxole](/NewsImg/2024-01-23/6384160275195768365581876.png "3,3-DiMethyl-1-[difluoro(phenylsulfonyl)Methyl]-1,2-benziodoxole")
(3) Difluoromethylation of α,β-unsaturated carboxylic acids.
![3,3-DiMethyl-1-[difluoro(phenylsulfonyl)Methyl]-1,2-benziodoxole](/NewsImg/2024-01-23/6384160276009714922267705.png "3,3-DiMethyl-1-[difluoro(phenylsulfonyl)Methyl]-1,2-benziodoxole")
| | References | [1] WEI ZHANG; Jinbo H; Jieming Zhu. Electrophilic (phenylsulfonyl)difluoromethylation of thiols with a hypervalent iodine(III)–CF2SO2Ph reagent[J]. Tetrahedron Letters, 2008. DOI:10.1016/j.tetlet.2008.06.064.
[2] ZHENGBIAO HE. Copper-Catalyzed Di- and Trifluoromethylation of α,β-Unsaturated Carboxylic Acids: A Protocol for Vinylic Fluoroalkylations?[J]. Angewandte Chemie International Edition, 2012, 51 16: 3944-3947. DOI:10.1002/anie.201200140.
[3] DR. ZHENGBIAO HE. Copper-Catalyzed Difluoromethylation of β,γ-Unsaturated Carboxylic Acids: An Efficient Allylic Difluoromethylation?[J]. Angewandte Chemie International Edition, 2012, 51 46: 11545-11547. DOI:10.1002/anie.201206556.
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| | 3,3-DiMethyl-1-[difluoro(phenylsulfonyl)Methyl]-1,2-benziodoxole Preparation Products And Raw materials |
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