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Product Name:Luotonine A
CAS:205989-12-4
Package:100Mg,10Mg,25Mg
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BioPharmaMatrix,Inc.
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CAS:205989-12-4
Package:10g m
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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Product Name:Luotonin A
CAS:205989-12-4
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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MedBioPharmaceutical Technology Inc
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Product Name:Luotonine A
CAS:205989-12-4
Purity:98% Package:5mg; 10mg; 25mg Remarks:Medbio
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| | Luotonine A Basic information |
| Product Name: | Luotonine A | | Synonyms: | Luotonine A;LUMDXNLBIYLTER-UHFFFAOYSA-N;Quino[2',3':3,4]pyrrolo[2,1-b]quinazolin-11(13H)-one | | CAS: | 205989-12-4 | | MF: | C18H11N3O | | MW: | 285.3 | | EINECS: | | | Product Categories: | | | Mol File: | 205989-12-4.mol |  |
| | Luotonine A Chemical Properties |
| Melting point | 283-285 °C | | Boiling point | 530.9±60.0 °C(Predicted) | | density | 1.44±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | ≤3mg/ml in DMSO;3mg/ml in dimethyl formamide | | form | crystalline solid | | pka | 1.61±0.20(Predicted) |
| | Luotonine A Usage And Synthesis |
| Description | Luotonin A is an alkaloid originally isolated from a plant used in traditional Chinese medicine. It inhibits the growth of mouse leukemia P388 cells (IC50 = 1.8 μg/ml). Luotonin A is structurally similar to the alkaloid camptothecin and, like camptothecin, it binds to and stabilizes the topoisomerase I-DNA binary complex, leading to DNA breakage and cell death (IC50 = 5.07-12.6 μM). Also like camptothecin, luotonin A forms non-covalent complexes with double-stranded DNA in the minor groove and this association can be followed by native fluorescence associated with the aromatic and heterocyclic ring structure. Luotonin A also selectively inhibits the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2 (IC50 = ~6 μM for each) in human liver microsomes. | | Uses | Luotonine A is a pyrroloquinoline alkaloid, a topoisomerase I inhibitor and a potent CYP1A inhibitor. | | Definition | ChEBI: Luotonin A is a member of quinazolines. | | in vitro | luotonin a was isolated as a pyrroloquinazolinoquinoline alkaloid from the chinese medicinal plant peganum nigellastrum. luotonin a could stabilize the human dna topoisomerase i-dna covalent binary complex and mediate topoisomerase i-dependent cytotoxicity in intact cells. similar to camptothecin, luotonin a was able to effect concentration-dependent stabilization of the enzyme-dna binary complex. however, neither camptothecin nor luotonin a had any measurable effect on dna in the absence of topoisomerase i. in addition, luotonin a was evaluated in a strain of saccharomyces cerevisiae lacking yeast topoisomerase i, but having a plasmid having the human topoisomerase i gene under the control of a galactose promoter. results showed that luotonin a at 1 μm concentration could produce 36% inhibition of growth in the presence of galactose. moreover, in replicate experiments, lutonin a exhibited ic50 values from 5.7 to 12.6 μm in the presence of galactose, while the comparable values for camptothecin were from 0.74 to 0.86 μm [1]. | | IC 50 | 1.8 μg/ml for p-388 cell line | | references | [1] cagir, a. ,jones, s.h.,gao, r., et al. luotonin a. a naturally occurring human dna topoisomerase i poison. journal of the american chemical society 125(45), 13628-13629 (2003). |
| | Luotonine A Preparation Products And Raw materials |
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