CS-1190
中文名称 | CS-1190 |
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中文同义词 | 3-均三甲苯基-3A,4,5,6,7,7A-六氢-4,7-亚甲基苯并[D]异恶唑;化合物SN 2;SN 2,TRPML3通道激活剂 |
英文名称 | SN 2 |
英文同义词 | 3a,4,5,6,7,7a-Hexahydro-3-(2,4,6-trimethylphenyl)-4,7-methano-1,2-benzisoxazole;CS-1190;SN2;SN-2;4,7-Methano-1,2-benzisoxazole, 3a,4,5,6,7,7a-hexahydro-3-(2,4,6-trimethylphenyl)-;inhibit,Transient receptor potential channels,SN-2,SN 2,TRP Channel,Inhibitor,SN2 |
CAS号 | 823218-99-1 |
分子式 | C17H21NO |
分子量 | 255.35 |
EINECS号 | |
相关类别 | |
Mol文件 | 823218-99-1.mol |
结构式 |
CS-1190 性质
沸点 | 370.8±52.0 °C(Predicted) |
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密度 | 1.27±0.1 g/cm3(Predicted) |
储存条件 | 2-8°C |
溶解度 | DMSO:100 mg/mL(391.62 mM;需要超声波) |
形态 | 粉末 |
颜色 | 白色至米白色 |
EC50: 1.8±0.13 μM (TRPML3), >29.9 μM (TRPML1)
The conductance of TRPML3 channels is estimate, when activated with 10 µM SN-2 is approximately 10 pS at −80 mV. TRPML3-expressing HEK293 cells are perfused with a series starting with compound alone (in SBS), with compound in ELS, and finally with ELS alone. Two representative compounds, SF-24 and SN-2, are tested. SF-24 is one of the least effective compounds, and SN-2 is one of the most active ones. SN-2 has a similar synergistic effect, also reaching up-to 10-fold enhancement of the combined response when compared with the individual responses, reaching average current densities of up to 3 nA/pF at −80 mV. Dominant negative TRPML3(D458K) is highly effective in eliminating SN-2-induced activity in epidermal melanocytes, suggesting that SN-2 activates a channel that is not responsive in presence of TRPML3(D458K). Such a dominant negative action might be attributed to potential heteromerization of TRPML3(D458K) with an SN-2-responsive channel.