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| Product Name: | ML 254 | | Synonyms: | ML 254;5-[2-(3-fluorophenyl)ethynyl]-N-(3-methyloxetan-3-yl)pyridine-2-carboxamide;5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinamide;2-Pyridinecarboxamide, 5-[2-(3-fluorophenyl)ethynyl]-N-(3-methyl-3-oxetanyl)-;ML 254,inhibit,ML254,ML-254,Inhibitor,Metabotropic glutamate receptors,mGluR,Schizophrenia | | CAS: | 1428630-86-7 | | MF: | C18H15FN2O2 | | MW: | 310.32 | | EINECS: | | | Product Categories: | | | Mol File: | 1428630-86-7.mol |  |
| | ML 254 Chemical Properties |
| form | Solid | | color | Off-white to light yellow |
| | ML 254 Usage And Synthesis |
| Description | ML-254, also known as VU0430644; is Positive Allosteric Modulators (PAMs) of mGlu5 with Competitive MPEP-Site Interaction. ML254 is highly selective for mGlu5 versus other mGlu receptors, has a clean ancillary Ricerca profile, and suitable dystrophia myotonica protein kinase (DMPK) properties for systemic dosing in rodents. Preliminary experiments at a single dose in an in vivo model of psychosis using ML254 demonstrates a robust reversal of amphetamine induced hyperlocomotion. ML254 will serve as a significant pure-PAM tool compound for the field with potential for studies within in vivo paradigms. Structure activity relationship (SAR) and characterization of ML254 are described. |
| | ML 254 Preparation Products And Raw materials |
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