| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:TTT 3002
CAS:871037-95-5
Package:50mg/RMB 36300;100mg/RMB 47500;25mg/RMB 27100
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| | TTT-3002 Basic information |
| Product Name: | TTT-3002 | | Synonyms: | TTT-3002;9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxamide, 10-amino-2,3,9,10,11,12-hexahydro-N,9-dimethyl-1-oxo-, (9S,10R,12R)- | | CAS: | 871037-95-5 | | MF: | C27H23N5O3 | | MW: | 465.50322 | | EINECS: | | | Product Categories: | | | Mol File: | 871037-95-5.mol |  |
| | TTT-3002 Chemical Properties |
| Boiling point | 770.4±60.0 °C(Predicted) | | density | 1.68±0.1 g/cm3(Predicted) | | pka | 14.18±0.60(Predicted) |
| | TTT-3002 Usage And Synthesis |
| Description | TTT-3002 is a tyrosine kinase inhibitor (TKI) that is one of the most potent FLT3 inhibitors discovered to date. Studies using human FLT3/ITD mutant leukemia cell lines revealed the half maximal inhibitory concentration (IC50) for inhibiting FLT3 autophosphorylation is from 100 to 250 pM. The proliferation IC50 for TTT-3002 in these same cells was from 490 to 920 pM. TTT-3002 also showed potent activity when tested against the most frequently occurring FLT3-activating point mutation, FLT3/D835Y, against which many current TKIs are ineffective. |
| | TTT-3002 Preparation Products And Raw materials |
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