| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:ZK-Thiazolidinone
CAS:891849-87-9
Purity:详情请点击官网 Package:1 mg
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| | ZK-Thiazolidinone Basic information |
| Product Name: | ZK-Thiazolidinone | | Synonyms: | ZK-Thiazolidinone;Acetamide, 2-cyano-2-[3-ethyl-4-oxo-5-[[[3-[2-(1-pyrrolidinyl)ethyl]phenyl]amino]methylene]-2-thiazolidinylidene]-N-(2,2,2-trifluoroethyl)- | | CAS: | 891849-87-9 | | MF: | C23H26F3N5O2S | | MW: | 493.55 | | EINECS: | | | Product Categories: | | | Mol File: | 891849-87-9.mol |  |
| | ZK-Thiazolidinone Chemical Properties |
| Boiling point | 604.8±55.0 °C(Predicted) | | density | 1.382±0.06 g/cm3(Predicted) | | pka | 10.77±0.46(Predicted) |
| | ZK-Thiazolidinone Usage And Synthesis |
| Description | ZK-Thiazolidinone, also known as TAL, is an ATP-competitive inhibitor of PLK1. In vitro, ZK-Thiazolidinone counteracts the role of Plk1 in previously established functions, notably, sister chromatid separation, centrosome maturation, and bipolar spindle assembly. In vivo, ZK-Thiazolidinone selectively inhibits PLK1 and causes a prometaphase-like mitotic (G2–M) arrest. ZK-Thiazolidinone inhibits human PLK1 (IC50, 19± 12 nM) and various human and mouse tumor cell lines (IC50, 0.2–1.3 μM). ZK-Thiazolidinone impairs centrosome maturation. |
| | ZK-Thiazolidinone Preparation Products And Raw materials |
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